Synthesis and Conformation of Poly(L-γ-Chloroethyl glutamate)

Abstract

Abstract: Triphosgene was used to react with γ-chloroethyl glutamate, which was synthesized from 2-ethylene chlorohydrin and L-glutamic acid, to give γ-chloroethyl glutamate N-carboxyan.hydride (NCA). Thus, poly(γ-chloroethyl glutamate), a new poly (amino acid) with reactive chloride, was obtained from the NCAby using triethylamine as the initiator which can lead to intrinsic viscosity of polypeptide, [η], over 50 mL/g. NCAand polymer were characterized by IR, ¹H NMRand ¹³C NMR. Oligomer of γ-chloroethyl glutamate was also obtained while NCAwas initiated by moisture in air. The conforma- tions of oligomer and polymer of γ-chloroethyl glutamate were observed by IRand CDspectroscopy. The results suggested that the conformation of oligomer mainly be β-sheet, while the polymer be α-helix.

Key words: Poly(amino acid), N-Carboxyanhydride(NCA), Conformation

CLC Number:

O631

TrendMD:

LIN Heng, SHAO Zheng-Zhong, ZHOU Ping, GAO Qin-Wei, YU Tong-Yin . Synthesis and Conformation of Poly(L-γ-Chloroethyl glutamate)[J]. Chem. J. Chinese Universities, 2000, 21(5): 819.

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Synthesis and Conformation of Poly(L-γ-Chloroethyl glutamate)

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