The Regulation of Mg(Ⅱ) to the Combination of Ciprofloxacin and Calf Thymus DNA

Abstract

Abstract: Using the method of fluorescence, the binding constants of ciprofloxacin(CPFX)-Mg(Ⅱ)and CPFX-calf thymus DNA(C. T. DNA), the formed quantity and the forming condition of ternary complex of CPFX-Mg(Ⅱ)-C.T.DNA have been determined. Adding Mg(Ⅱ) to the binary system of CPFX with C.T.DNA, the binding quantity of CPFXwith C.T.DNAincreases to the largest, then decrease up to zero in the end as the increase of the concentration of Mg(Ⅱ). The result shows the amount of CPFX bound to C.T.DNA is modulated by Mg(Ⅱ), and in the concentration of Mg(Ⅱ) precented in eucaryotic organism cytoplasm, CPFX has no obvious combination with C. T. DNA.

Key words: Ciprofloxacin, Calf thymus DNA, Mg(Ⅱ), Ternary complex, Fluorescence

CLC Number:

O626.1

TrendMD:

GUO Dong-Sheng, YUAN Xiao-Ying . The Regulation of Mg(Ⅱ) to the Combination of Ciprofloxacin and Calf Thymus DNA[J]. Chem. J. Chinese Universities, 1999, 20(4): 584.

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The Regulation of Mg(Ⅱ) to the Combination of Ciprofloxacin and Calf Thymus DNA

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