Syntheses and Biological Activities of 2-Arylamidothioacyl-3-isothiozolones and 4-Cyano-5-methylthio-2-arylamidothioacyl-3-isothiozolones

Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (3): 395.

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Syntheses and Biological Activities of 2-Arylamidothioacyl-3-isothiozolones and 4-Cyano-5-methylthio-2-arylamidothioacyl-3-isothiozolones

YANG Xiao-Ping, LI Zheng-Ming, CHEN Han-Song, LIU Jie, LI Shu-Zheng

Research Institute of Elementoorganic Chemistry, Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin, 300071

Received:1998-04-24 Online:1999-03-24 Published:1999-03-24

Abstract

Abstract: Novel compounds, 2-arylamidothioacyl-3-isothiozolones 6 and 4-cyano5-methylthio-2-arylamidothioacyl-3-isothiozolones 7 were synthesized by reacting of 3-hydroxyisothiozoles(4, 5) with aryLIsothiocyanates 3 . The unique coupling constants of 4-H and 5-H of isothiazole ring of compounds 6 were discovered and explained according to the coplanarity of isothiazole ring with thioacyl group. The preliminary test of fungicidal activity showed that some of the title compounds possessed promising activity.

Key words: Isothiozole, Acyl thiourea, Synthesis, Fungicidal activity

CLC Number:

O626

TrendMD:

YANG Xiao-Ping, LI Zheng-Ming, CHEN Han-Song, LIU Jie, LI Shu-Zheng . Syntheses and Biological Activities of 2-Arylamidothioacyl-3-isothiozolones and 4-Cyano-5-methylthio-2-arylamidothioacyl-3-isothiozolones[J]. Chem. J. Chinese Universities, 1999, 20(3): 395.

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Syntheses and Biological Activities of 2-Arylamidothioacyl-3-isothiozolones and 4-Cyano-5-methylthio-2-arylamidothioacyl-3-isothiozolones

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