Abstract: Three α, β-poly(L-aspartic acid) derivatives cis platin conjugates were synthesized by conjugation of α,β-poly(Laspartic acid), (α,β,L-aspartic acid) [ α,β,L-(Nhydroxyethyl) aspartamide] copolymer and [ α,β,L-(N-hydroxyethyl) aspartamide]-[ α,β,L-(N-succinyl) aspartamide] copolymer with cis-dichlorodiammine platinum(Ⅱ) respectively. The polymer carriers were characterized by IR, GPC and intrinsic viscosity. The influence of pHon the conjugation reaction was studied. Cytotoxicity of polymer-cis-platin conjugates was tested against cervix uteri Hela cells in vitro . The cytotoxicity of polymer-cis-platin conjugates increases with the increase of concentration of the congugates, but lower than cis-platin of the corresponding concentration.

Key words: Polymer antitumor drug, Polymer-cis-platin conjugates, Cytotoxicity