The Synthesis and Biological Activity of N-(4,6-Dimethoxy-2-pyrimidinyl)-N'-phosphoryl Urea Derivatives

Abstract

Abstract: In this paper N-(4,6-dimethoxY-2-pyrimidinyl)-N'-dichloro-phosphoryl urea(Ⅰ) was synthesized by addition reaction of dichloro phosphoryl isocyanate with 4,6-dimethoxY-2-aminopyrimidine. Compound Ⅰ reacted with two equivalents of amines or alcohols to obtain symmetric disubstituted phosphoryl urea derivatives Ⅱa_Ⅱi, and reacted with one equivalent of amines to give monochlorophosphoryl ureas Ⅲa_Ⅲe which reacted with one equivalent of alcohols to obtain asymmetric disubstituted phosphoryl urea derivatives Ⅳa_ Ⅳg. The biological tests indicated that compounds Ⅱ, Ⅲ and Ⅳ showed herbicidal activities.

Key words: Phosphoryl urea, Addition reaction, Synthesis, Biological activity

CLC Number:

O622

TrendMD:

ZHAO Guo-Feng, YANG Hua-Zheng, WANG Ling-Xiu . The Synthesis and Biological Activity of N-(4,6-Dimethoxy-2-pyrimidinyl)-N'-phosphoryl Urea Derivatives[J]. Chem. J. Chinese Universities, 1998, 19(4): 555.

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The Synthesis and Biological Activity of N-(4,6-Dimethoxy-2-pyrimidinyl)-N'-phosphoryl Urea Derivatives

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