Synthesis and Biological Activity of Biscyano Substituted Acyclic Ketene Aminals Containing2-Chloro-5-pyridylmethyl Group

Abstract

Abstract: In this paper, 2-cyano-3-(2-chloro-5-pyridylmethyl)amino-3-methylthioacrylonitrile 9 was synthesized. By the reaction of 9 as an intermediate with amines, nineteen new biscyano substituted acyclic ketene aminals containing 2-chloro-5-pyridylmethyl group were prepared. When 9 reacted with hydrazine, the corresponding cyclic compounds 10p was obtained. Preliminary bioassays show that 9 has a potential activity against aphid and the compounds 10a, 10f, 10g and 10r in this series have a good herbicidal activity.

Key words: 2-Chloro-5-pyridylmethyl, Cyano, Ketene aminal, Biological activity

CLC Number:

O625.63

TrendMD:

ZHAO Yi-Gang, HUANG Run-Qiu, CHENG Mu-Ru, LI Hui-Ying, CHENG Jun-Ran . Synthesis and Biological Activity of Biscyano Substituted Acyclic Ketene Aminals Containing₂-Chloro-5-pyridylmethyl Group[J]. Chem. J. Chinese Universities, 1998, 19(10): 1620.

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Synthesis and Biological Activity of Biscyano Substituted Acyclic Ketene Aminals Containing₂-Chloro-5-pyridylmethyl Group

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