Studies on Platelet-Resistance of Amphiphilic Polystyrenegraft-ω-stearyl-poly(ethylene oxide)

Abstract

Abstract: The platelet adhesion and protein(Fibrinogen and albumin) adsorption ontoamphiphilic polystyrene-graft-poly(ethylene oxide) (PS-g-PEO) and polystyrene-graft -ω-stearyl-poly(ethyleneoxide) (PS-G-SPEO) were investigated.It was found that the plateletadhesion on PS-g-SPEOwas lower than that on PS-g-PEO.The PS-g-SPEOsurface shows apreference for Albumin, while the PS-g-PEOsurface absorbed Fibrinogen selectivelyu.Twoeffects of stearyl end group on PS-g-SPEOsurface: (1) the lower surface free energe leadsto SPEOenrich at surface; (2) the stearyl end group absorbed albumin selectively, seems tocontribute to resistant the platelet adhesion.So the polymer surface modificed by both stearylgroup and poly(ethylene oxide) chain may be a new ideal way to improve material's bloodcompatibility.

Key words: Amphiphilic copolymer, Blood, compatilility, Platelet adhesion, Protein adsorption

CLC Number:

O632.13

TrendMD:

JI Jian, SUn Yong-Hog, Tong Feng-Oin, QIU Yong-Xing, FENG Lin-Xian. Studies on Platelet-Resistance of Amphiphilic Polystyrenegraft-ω-stearyl-poly(ethylene oxide)[J]. Chem. J. Chinese Universities, 1997, 18(11): 1899.

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Studies on Platelet-Resistance of Amphiphilic Polystyrenegraft-ω-stearyl-poly(ethylene oxide)

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