Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (11): 1809.

• Articles • Previous Articles     Next Articles

Synthesis of Glycerophospholipid Conjugates of Uridine

ZHANG Cheng-Xiang, ZHANG Zhong-Biao, TANG Chu-Chi, CHEN Huan-Ming, CHI Guo-Chen, CHEN Ru-Yu   

  1. Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1996-09-03 Online:1997-11-24 Published:1997-11-24

Abstract: New structural liponucleoside prodrugs were prepared in which uridine wascovalently attached to cyclic phospholipids.The strategy for the synthesis used hexaethylphosphorous triamide, activated by a catalytic amount of iodine, as the phosphorylating reagentin a one-pot reaction resulting in a number of phospholipid-uridine conjugates.The celltoxicity experiments show that the compounds have certain selective antitumor activities.

Key words: Uridine, Cyclicglycerophospholipid, Thiophosphate, Cytotoxicity

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