The Inhibition of FcT on the Biosynthesis of DNA in Ehrlich Ascites Cancer Cells

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (8): 1177.

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The Inhibition of FcT on the Biosynthesis of DNA in Ehrlich Ascites Cancer Cells

GUO Mao-Lin¹, YANG Pin¹, ZHAO Chun-Gui¹, YANG Bin-Sheng¹, YANG Wei-Ping²

1. Institute of Molecular Science, Shanxi University, Taiyuan, 030006;
2. Department of Tumour, Coal Central Hospital of Shanxi

Received:1994-09-29 Revised:1994-12-30 Online:1995-08-24 Published:1995-08-24

Abstract

Abstract: The effect of FcT[Ferricenium trichloroacetate,bis(trichloroacetic acid)solvate] on the biosynthesis of DNA in EAC cells in vitro was reported in this paper. The experimtal results show that FcT,similar to another anticancer agent titanocene dichloride(TDC),caused a remarkable depression of DNA synthesis activities,and the half-inhibition concentration for FcTis about 1. 0× 10^-4mol/L. The irreversible and long-lasting inhibition manner of FcTon DNA biosynthesis indicated that the DNA template was injured by FcT. Meanwhile,the fluorescent quenching of DNA-EB complex by FcT revealed that the DNA duplex might be damaged by FcT.

Key words: Ferricenium salts, Anticancer agents, DNA

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GUO Mao-Lin, YANG Pin, ZHAO Chun-Gui, YANG Bin-Sheng, YANG Wei-Ping. The Inhibition of FcT on the Biosynthesis of DNA in Ehrlich Ascites Cancer Cells[J]. Chem. J. Chinese Universities, 1995, 16(8): 1177.

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The Inhibition of FcT on the Biosynthesis of DNA in Ehrlich Ascites Cancer Cells

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