Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (2): 237.

• Articles • Previous Articles     Next Articles

Synthesis and Configurational Determination of 11-Chloroartemisinin

LU De-Wen, LI Ying   

  1. Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, 200031
  • Received:1994-05-12 Revised:1994-09-10 Online:1995-02-24 Published:1995-02-24

Abstract: Chloroartemisinin,a new derivative of artemisinin,was prepared by treating 11α-hydroxyartemisinin with SOCl2/Pyr with retention of configuration.11-Chloro atom having α orientation was determinated by NMR technique and molecular mechanic calculation.

Key words: 11-Chloroartemisinin, Synthesis, Configuration

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