Abstract: Three electron donor-acceptor amphiphilic compounds with barbituric acid were designed and synthesized.All the compounds have not been reported so far and their structures have been confirmed by elementary analysis,¹H NMR and IR.The reactions of aldehydes with barbituric acid were studied,and it is found that,in the basic media,the reaction rates were immeasurably slow,however,in the neutral media,the rates were very fast.The relationship among reaction activities of aldehydes,the NMR chemical shifts of their hydrogens connected with carbonyl group,and their carbonyl groups characteristic infrared absorption,were also studied.

Key words: Barbituric acid group, Electron donor-acceptor, Amphiphilic, Synthesis