Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (12): 1899.

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Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates

CHEN Xiao-Ru, CHEN Ru-Yu, LI Hui, MAO Li-Juan

Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071

Received:1994-12-01 Revised:1995-03-03 Online:1995-12-24 Published:1995-12-24

Abstract

Abstract: A series of novel O-saccharidyl-methoxyformylphosphosphonamidates were synthesized,and Arbuzov reaetions of O-saccharidylphosphoramidites with methyl chloroformate and other related reactions were disussed.The structures of the products were determined by ¹HNMR,³¹PNMR, IR and elemental analyses. The results of preliminary biological tests showed that compound 3_cpossessed some inhibitory activities against Leukaemia HL-60 cells and liver cancer Bel-7402 cells in vitro,compound 3_ahas some antivirus activity against tobacco mosaic virus(TMV).

Key words: Formylphosphonamidate, Arbuzov reaction, Anticancer activity, Antivirus activity

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CHEN Xiao-Ru, CHEN Ru-Yu, LI Hui, MAO Li-Juan. Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates[J]. Chem. J. Chinese Universities, 1995, 16(12): 1899.

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Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates

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