Synthesis of N,N-bis(2-chloroethyl) Fructopyranosyl- phosphoramidates and Their Antitumor Activities

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (7): 963.

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Synthesis of N,N-bis(2-chloroethyl) Fructopyranosyl- phosphoramidates and Their Antitumor Activities

CHEN Ru-Yu, CHEN Xiao-Ru

Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071

Received:1992-10-12 Revised:1993-02-17 Online:1993-07-24 Published:1993-07-24

Abstract

Abstract: In this paper, a series of new N, N-bis(2-chloroethyl) fructopyranosyl phosphoramidates were synthesized by the reaction between phosphorus oxychloride and 2,3:4,5-di-O-isopropylidene-Dructopyranse(1).The structures of all compounds prepared were determined by ¹H NMR, IRand elemental analysis.The existence of diastereoisomers were proved by ³¹P NMR, but only one pure iso-mer was isolated by recrystallization.The results of preliminary biological tests indicated that the title compounds had the inhibition effect against L1210 cells and 5-180 tumors.

Key words: Phosphoramidate, Synthesis, Antitumor activity

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CHEN Ru-Yu, CHEN Xiao-Ru . Synthesis of N,N-bis(2-chloroethyl) Fructopyranosyl- phosphoramidates and Their Antitumor Activities[J]. Chem. J. Chinese Universities, 1993, 14(7): 963.

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Synthesis of N,N-bis(2-chloroethyl) Fructopyranosyl- phosphoramidates and Their Antitumor Activities

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