Syntheses of 7,10-Diaryl-hexahydro(tetrahydro)benzo[C]acridin-8-ones

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (6): 806.

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Syntheses of 7,10-Diaryl-hexahydro(tetrahydro)benzo[C]acridin-8-ones

WANG Jin-Jun¹, HAN Guang-Fan², YIN Rong², JIANG Gui-Ji³

1. Dept, of Fine Chem.Technology, Jilin Chem.Industry Instu;
2. Dept.of Medical Lab., Jilin Medial College;
3. Department of Chemistry, Yanbian University, Yanji, 133002

Received:1992-05-19 Revised:1993-03-09 Online:1993-06-24 Published:1993-06-24

Abstract

Abstract: Syntheses of 7, 10-diaryl-7,8,9,10,11, 12-hexahydro-benzo[C]acridin-8-ones (la-g) were achieved by reaction of 5-aryl-1, 3-cyclohexanedione, α-naphthylamine and the appropriate aromatic aldehydes in ethanol or benzene.The oxidation of compounds la-g with CrO₃ in acetic acid giving 7, 10-diaryl-8, 9, 10, 11-tetrahydrobenzo[C]-acridin-8-ones (2a-g) is also reported.The structures of 14 new compounds were characterized by elementary analysis, IR, and ¹H NMRspectra.The preliminary pharmacodynamic experiments show that compounds Ic, 1f, 2f possess a significant inhibition effect on the growth of KBcell.

Key words: Benzoacridinone, Organic synthesis, Anticancer activity

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WANG Jin-Jun, HAN Guang-Fan, YIN Rong, JIANG Gui-Ji. Syntheses of 7,10-Diaryl-hexahydro(tetrahydro)benzo[C]acridin-8-ones[J]. Chem. J. Chinese Universities, 1993, 14(6): 806.

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Syntheses of 7,10-Diaryl-hexahydro(tetrahydro)benzo[C]acridin-8-ones

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