Chem. J. Chinese Universities ›› 1991, Vol. 12 ›› Issue (8): 1056.

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Studies on Acylthioscmicarbazides and Related Heterocyclic Derivatives (XⅦ)--Synthesis of Some l-Arylformyl-4-[4'-(2,2,6,6-Tetramethyl-Piperidine)-l-Oxy]Thioscmicarbazidcs Compounds

Zhang Zi-yi1, Shi Ji-cheng1, Zheng Rong-liang2, Zhou Yan-chun2   

  1. 1. Department of Chemistry, Lanzhou University, National Laboratory of Applied Organic Chemistry, Lanzhou, 730000;
    2. Department of Biology, Lanzhou University, Lanzhou
  • Received:1990-04-20 Online:1991-08-24 Published:1991-08-24

Abstract: Twenty one 1-arylformyl-4-[4'-(2, 2, 6, 6-tetramethyl-piperidine)-1-oxy] thiosemicar-bazides were synthesized. Their structures were ascertained. And the characters of IR, MS and ESR spectra were discussed. The results of the preliminary experiment show that compounds(5) possess an inhibiting activity on L7712-Lekemia cell.

Key words: Acylthiosemicarbazides, Piperidine nitroxide, Anticancer activity

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