Structure Determination of a Novel Sterol--Clavisterol A

Abstract

Abstract: A novel marine C₃₀-sterol clavisterol Awith an interesting cyclopropane moiety side chain, was isolated from the Chinese soft coral Clavularia viridis collected from Xisha Islands in the South China Sea. The crude methanol-CHCl₃(10:1) extract was chromatographed to obtain the crude clavis-terol Afrom the cyclohexane (9%) ethyl acetate eluting portion. Pure clavisterol Ais a needle crystal, m.p. 158-160℃ (from acetone/p. ether), [A]_D²⁰-2.5(CHCl₃, C, 0.0233), molecular formula C₃₀H₅₀O, (HRMS, M⁺426. 3862). From the IR, MS, NMR data and comparing the data with those of cholesterol and stoloniferone-d, the structure of clavisterol Awas designed as 1.

Key words: Soft coral, Sterol, Structure determination

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Su Jing-yu, Zhong Yong-li, Zeng Long-mei . Structure Determination of a Novel Sterol--Clavisterol A[J]. Chem. J. Chinese Universities, 1991, 12(1): 49.

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Structure Determination of a Novel Sterol--Clavisterol A

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