Synthesis of aminoalkyl naphthol analogues and their anti-fungal and nematicidal activities

doi:10.7503/cjcu20250031

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Synthesis of aminoalkyl naphthol analogues and their anti-fungal and nematicidal activities

ZHANG Qilin^1,2,3, SHI Yanchang^2,3, GAO Kun^2,3, WANG Linsong^2,3, SONG Yadong^2,3, WANG Yusen^2,3, LI Pengcheng^2,3, LIU Song^2,3, XING Ronge^2,3, SONG Lin¹, QIN Yunkun^2,3

1.Bioengineering College, Qingdao University of Science and Technology
2.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
3.Functional laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center

Received:2025-01-28 Revised:2025-03-28 Online First:2025-03-29 Published:2025-03-29
Contact: QIN Yunkun E-mail:ykqin@qdio.ac.cn
Supported by:
Supported by the National Natural Science Foundation of China (No. 42076126), Shandong Key R&D Plan, Major Scientific and Technological Innovation Project (No. 2022CXGC020413), Qingdao Science and Technology Benefit the People Demonstration Project (No. 25-1-5-xdny-7-nsh), Special Project on Modern Agricultural Industry Technology System (No. CARS-49)

1. ESM to 20250031.pdf(1359KB)

Abstract

Abstract: With the rapid development of modern agriculture, the problems of plant fungal diseases and nematodes are becoming more and more prominent, seriously threatening agricultural production. Therefore, the search for a new, efficient and environmentally friendly pesticide active substance has become an important issue in current agricultural scientific research. In this study, in order to discover a new class of pesticide active substances with both anti-fungal and nematicidal activities, a series of aminoalkyl naphthol analogs were designed and synthesized for the first time by a one-pot, three-component method consisting of aldehyde, acetonitrile/amide/urea and 2-naphthol and their anti-pathogenic fungal and nematicidal activities were tested. The inhibitory activity of compound 10 against Alternaria alternata was about 50 % within the concentration range of 200 μg/mL to 25 μg/mL, with no significant concentration dependence. In addition, in vivo curative experiment against A. alternate found that compound 10 had comparable therapeutic action to the positive control azoxystrobin at 50 μg/mL. Meanwhile, target compound had signi?cant control e?cacy on Meloidogyne incognita under the greenhouse test-tube assay. Compound 14 could signi?cantly reduce the number of root knots at 10 μg/mL, at which the inhibition rate was about 90.91 %, which was comparable to that of the positive control fluopyram. The present work indicates that amidoalkyl naphthol can be used as promising candidates for the development of anti-phytopathogenic fungal and nematicidal activity agents.

Key words: One pot method, Amidoalkyl naphthol, Anti-fungal activity, Nematicidal activity

CLC Number:

O625

TrendMD:

ZHANG Qilin, SHI Yanchang, GAO Kun, WANG Linsong, SONG Yadong, WANG Yusen, LI Pengcheng, LIU Song, XING Ronge, SONG Lin, QIN Yunkun. Synthesis of aminoalkyl naphthol analogues and their anti-fungal and nematicidal activities[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20250031.

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Synthesis of aminoalkyl naphthol analogues and their anti-fungal and nematicidal activities

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