Chem. J. Chinese Universities ›› 2025, Vol. 46 ›› Issue (8): 20250031.doi: 10.7503/cjcu20250031

• Organic Chemistry • Previous Articles     Next Articles

Synthesis of Aminoalkyl Naphthol Analogues and Their Anti-fungal and Nematicidal Activities

ZHANG Qilin1,2,3, SHI Yanchang2,3, GAO Kun2,3, WANG Linsong2,3, SONG Yadong2,3, WANG Yusen2,3, LI Pengcheng2,3, LIU Song2,3, XING Ronge2,3, SONG Lin1(), QIN Yukun2,3()   

  1. 1.Bioengineering College,Qingdao University of Science and Technology,Qingdao 266042,China
    2.Key Laboratory of Experimental Marine Biology,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China
    3.Functional Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center,Qingdao 266237,China
  • Received:2025-01-28 Online:2025-08-10 Published:2025-03-29
  • Contact: QIN Yukun E-mail:03231@qust.edu.cn;ykqin@qdio.ac.cn
  • Supported by:
    the National Natural Science Foundation of China(42076126);the Shandong Key Research and Development Plan, Major Scientific and Technological Innovation Project, China(2022CXGC020413);the Qingdao Science and Technology Benefit the People Demonstration Project, China(25-1-5-xdny-7-nsh);the Central Guidance for Local Scientific and Technological Development Funds, China(2024ZY0039);the Special Project on Modern Agricultural Industry Technology System, China(CARS-49)

Abstract:

A series of amino-alkyl naphthol compounds was synthesized through a one-pot threecomponent reaction, their antifungal activity against plant pathogenic fungi and nematicidal activity were evaluated. The results showed that compound 8 exhibited about 50% inhibitory activity against Alternaria alternate at concentrations ranging from 200 μg/mL to 25 μg/mL, and the inhibitory effect was not significantly correlated with concentration. In vivo antifungal experiments indicated that compound 8 at a concentration of 50 μg/mL had a therapeutic effect comparable to the positive control pyrimethanil. Additionally, in greenhouse test tube experiments, the synthesized compounds showed significant inhibitory activity against southern root-knot nematodes, with compound 10 significantly reducing the number of galls at a concentration of 10 μg/mL, achieving an inhibition rate of 90.91%, which is comparable to the positive control fluopyram. In summary, amino-alkyl naphthol compounds, as a new type of pesticide active substance, have potential dual effects of antibiosis and nematicide, and the aforementioned research provides new ideas for the development of environmentally friendly multi-target pesticides.

Key words: One pot method, Amidoalkyl naphthol, Anti-fungal activity, Nematicidal activity

CLC Number: 

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