Chem. J. Chinese Universities ›› 2022, Vol. 43 ›› Issue (12): 20220556.doi: 10.7503/cjcu20220556

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Advances of Optical Probes in Atherosclerosis Imaging

YE Zhuo1,2, JI Moxuan2, LIU Dingbin2()   

  1. 1.School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China
    2.College of Chemistry and State Key Laboratory of Medicinal Chemical Biology,Nankai University,Tianjin 300071,China
  • Received:2022-08-20 Online:2022-12-10 Published:2022-10-10
  • Contact: LIU Dingbin E-mail:liudb@nankai.edu.cn
  • Supported by:
    the National Key Research and Development Program of China(2019YFA0210100);the National Natural Science Foundation of China(22174072)

Abstract:

Cardiovascular disease(CVD) is the leading cause of death worldwide. Atherosclerosis(AS) is the primary risk factor for all kinds of CVD, and its occurrence and development usually undergo a continuous chronic inflammatory process. Therefore, timely and efficient detection of AS has important clinical significance for early evaluation, diagnosis and treatment of CVD. Optical probes are widely used in biomedical detection and imaging because of their high sensitivity and spatial resolution as well as its ultra-fast signal acquisition and processing speed. This paper reviewed six common optical probes for AS imaging, involving small-molecule fluorescent probes, aggregate-induced emission(AIE) nanoprobes, quantum dot probes, upconversion nanoprobes, photoacoustic probes, and multi-modal probes. The advantages and disadvantages of various probes were also comparably analyzed. Based on this, we prospected the development prospects of optical probes in the field of AS imaging and put forward four suggestions.

Key words: Optical probe, Atherosclerosis, Bioimaging

CLC Number: 

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