Chem. J. Chinese Universities ›› 2022, Vol. 43 ›› Issue (12): 20220552.doi: 10.7503/cjcu20220552

• Review • Previous Articles     Next Articles

High-resolution in vivo Imaging, Diagnosis and Treatment Applications of Rare-earth-based Nanomaterials

ZHANG Qian1, LIU Yawei2(), WANG Fan2, LIU Kai1,2(), ZHANG Hongjie1,2   

  1. 1.Engineering Research Center of Advanced Rare Earth Materials,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China
    2.State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
  • Received:2022-08-19 Online:2022-12-10 Published:2022-11-08
  • Contact: LIU Yawei, LIU Kai E-mail:yaweiliu@ciac.ac.cn;kailiu@tsinghua.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(22020102003)

Abstract:

Fluorescence imaging with the advantages of high spatiotemporal resolution, fast feedback, non-invasiveness, and no ionizing radiation is an important bioimaging technology. Compared with the traditionally used visible and first near-infrared(NIR-I, 650—950 nm) windows, the second near-infrared(NIR-Ⅱ, 1000—1700 nm) window has lower scattering coefficients and biological autofluorescence, thus effectively improving the resolution, signal-to-noise ratio and penetration depth of bioimaging. Rare-earth-based nanoparticles(RENPs) possess large Stokes shift, high chemical stability, tunable fluorescence lifetimes, and narrow emission bands, making them important fluorescent imaging probes. In recent years, a series of RENPs with excellent NIR-Ⅱ fluorescence properties have been developed and applied to high-resolution in vivo fluorescence imaging, disease diagnosis and therapy. Herein, the recent research progress of RENPs in high-resolution in vivo fluorescence imaging and theranostics is comprehensively reviewed. Strategies for NIR-Ⅱ emission enhancement of RENPs, such as dopant regulation, matrix lattice selection, and composite sensitization, are summarized. And their functions of targeting accumulation, fluorescence sensing, disease diagnosis and treatment in multiple biomedical scenes are also introduced. Moreover, their applications in multiplexed imaging, multimodal imaging, and disease diagnosis and treatment are highlighted. Finally, a brief perspective for the future development and challenges of RENPs in biomedical applications is presented.

Key words: Rare-earth-based nanomaterial, High-resolution fluorescence imaging, In vivo bioimaging, Biomedical application

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