Chem. J. Chinese Universities ›› 2021, Vol. 42 ›› Issue (11): 3406.doi: 10.7503/cjcu20210510

• Review • Previous Articles     Next Articles

Recent Progress of Aptamer Functionalized Two-dimensional Materials Field Effect Transistor Sensors

XIE Chen, CHEN Na, YANG Yanbing(), YUAN Quan   

  1. College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China
  • Received:2021-07-16 Online:2021-11-10 Published:2021-08-26
  • Contact: YANG Yanbing E-mail:yangyanbing@whu.edu.cn
  • Supported by:
    the National Key R&D Program of China(2017YFA0208000);the National Natural Science Foundation of China(21925401);the Fundamental Research Funds for the Central Universities of China(2042021kf0036)

Abstract:

Two-dimensional materials field-effect transistor sensors with adjustable electrical properties have been viewed as potential candidates for the design of high performance sensors for disease diagnosis and environmental monitoring. As a kind of nucleic acid molecules with recognition capability, aptamer exhibits high specificity and excellent stability for target molecules. In recent years, remarkable progress has been achieved in the field of aptamer functionalized two-dimensional materials field-effect transistor sensors. In this review, the latest research progress of aptamer functionalized two-dimensional materials field-effect transistor sensors is summarized. The structure and sensing principle of field-effect transistor sensors are illustrated. The preparation methods of two-dimensional materials and the design principle of aptamer functionalized sensors are comprehensively reviewed. For a further step, the application of aptamer functionalized two-dimensional materials field-effect transistor sensors in the field of disease diagnosis and environmental monitoring is summarized. Finally, the challenges and prospects of aptamer functionalized two-dimensional materials field-effect transistor sensors are discussed.

Key words: Aptamer, Field-effect transistor, Sensor, Two-dimensional material, Monitoring

CLC Number: 

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