Investigation of Vesiculation of Conjugated Linoleic Acid Assisted by Monolauryl Phosphate†

doi:10.7503/cjcu20170057

Abstract

Abstract:

A safe and mild anionic surfactant monolauryl phosphate(MLP) was blend with conjugated linoleic acid(CLA) that acted as the model fatty acid, and the vesiculation of CLA was observed in the weakly acidic to neutral pH range by DLS and TEM. Various charged species of the above two molecules with pH variation were investigated by means of pH titration, and molecular interaction among these species was reasoned. The impetus driving vesiculation of CLA assisted by MLP in the weakly acidic to neutral pH range was ascribed to hydrogen bonding and ion dipole interaction between CLA and MLP.

Key words: Fatty acid vesicle, Vesiculation, pH window, Monolauryl phosphate, Conjugated linoleic acid

CLC Number:

O648

TrendMD:

LIANG Xiaodan, FAN Ye, FANG Yun, XIA Yongmei, CHENG Ruohui. Investigation of Vesiculation of Conjugated Linoleic Acid Assisted by Monolauryl Phosphate^†[J]. Chem. J. Chinese Universities, 2017, 38(9): 1639.

Figures/Tables 5

Fig.1 Effect of molar fraction(x) on the pH window for vesiculation of CLA(3 mmol/L)-MLP x: (A) 0.5; (B) 0.33; (C) 0.2; (D) 0.09; (E) 0.05.

Fig.2 Characterization of vesiculation of CLA(3 mmol/L)-MLP(x =0.5)(A)Dh measured by DLS; (B) TEM images; (C) size distribution from TEM corresponding to pH of 3.0(A1—C1), 7.0(A2—C2) and (3) 8.5(A3—C3).

Fig.3 Characterization of CLA(3 mmol/L)-MLP with the variation x values at pH=6.5(A) TEM images; (B) estimation of bilayer thicknesses; (C) size distributions from TEM; (D) Dh measured by DLS. x: (A1—D1) 0.5; (A2—D2) 0.33; (A3—D3) 0.2; (A4—D4) 0.09.

Fig.4 Additional TEM images(insets) and size distributions from TEM of CLA(3 mmol/L)-MLP (A) x=0.2, pH=4.5; (B) x=0.2, pH=7.5; (C) x=0.09, pH=6.5; (D) x=0.09, pH=8.5.

Fig.5 Schematic illustration of the molecular interaction between MLP and CLA depending on alkaline titration curve of MLP(1 mmol/L)(A) and zeta potential curve of CLA(3 mmol/L)-MLP(x=0.5) system(B)

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