Oxidative DNA Cleavage Mediated by Water-soluble Carboxyl Iron(Ⅲ) Corrole

doi:10.7503/cjcu20130610

Abstract

Abstract:

A new water-soluble iron corrole, 5,10,15-tris[4-(carboxy)phenyl] corrolato-iron(Ⅲ)(Fe^ⅢTCPC), was synthesized and characterized. UV-Vis, fluorescence and CD spectra, as well as relative viscosity were used to study the interaction between Fe^ⅢTCPC and ct-DNA. Agarose gel electrophrosis was also carried out to investigate the oxidative cleavage ability of Fe^ⅢTCPC to pBR322 DNA in the presence of hydrogen peroxide(H₂O₂) or tert an outside binding mode with intrinsic binding constant K_b of 1.96×10⁵ L·mol^-1. In the presence of H₂O₂ or TBPH, Fe^ⅢTCPC exhibits good oxidative cleavage activity toward pBR322 DNA, and TBPH shows a higher oxidative efficiency. Inhibitor tests reveal that neither the hydroxyl radicals nor singlet oxygen is involved in Fe^ⅢTCPC mediated DNA oxidative cleavage. It is suggested that (oxo)iron(V) corrole is the possible active intermediate involved in DNA oxidative damage.

Key words: Corrole, Iron, DNA, Oxidative cleavage

CLC Number:

O614.81

TrendMD:

ZHANG Yang, CHEN Huan, WEN Jin-Yan, WANG Xiang-Li, WANG Hui, JI Liang-Nian, LIU Hai-Yang. Oxidative DNA Cleavage Mediated by Water-soluble Carboxyl Iron(Ⅲ) Corrole[J]. Chem. J. Chinese Universities, 2013, 34(11): 2462.

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