Coassembly of Palmitic Acid Modified α-Helical Peptide Amphiphiles

doi:10.7503/cjcu20120524

Abstract

Abstract:

Three peptide amphiphiles(PAs) composed of a palmitic acid and three heptad repeat peptide sequences, C₁₅H₃₁ CO-(AEELAKK)₃-NH₂(PA1), C₁₅H₃₁ CO-(AEALAKK)₃-NH₂(PA2) and C₁₅H₃₁CO-(AEELAKA)₃-NH₂(PA3), were designed and synthesized. The self-assembly behavior, mechanisms of PA1, PA2, PA3 and the coassembly behavior of PA2 and PA3 mixture were investigated. The circular dichroism(CD) spectra suggested that the secondary structures of PAs were mainly α-helical structures. The α-helical structure contents of the \{positively charged PA2 and negatively charged PA3 mixture increased. The morphologies of PA1, PA2, PA3 and PA2+PA3(volume ratio 1: 1) were investigated by transmission electron microscope(TEM). The TEM results indicated that the mixture of PA2 and PA3 formed nanofibers. The critical micelle concentration values of peptides self-assembly and coassembly were calculated by pyrene probe fluorescence.

Key words: Peptide amphiphile, α-Helix, Coassembly, Micelle, Nanofibers, Pyrene fluorescence probe

CLC Number:

O629.72

TrendMD:

KOU Ying-Ying, MENG Qing-Bin, LIU Ke-Liang. Coassembly of Palmitic Acid Modified α-Helical Peptide Amphiphiles[J]. Chem. J. Chinese Universities, 2012, 33(11): 2476.

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Coassembly of Palmitic Acid Modified α-Helical Peptide Amphiphiles

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