Transmembrane Delivery of Rich Arginine Peptide Modified Gold Nanoparticles

doi:10.3969/j.issn.0251-0790.2012.04.013

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (04): 714.doi: 10.3969/j.issn.0251-0790.2012.04.013

• Analytical Chemistry • Previous Articles Next Articles

Transmembrane Delivery of Rich Arginine Peptide Modified Gold Nanoparticles

SHAN Hong-Yan¹, YU Bo¹, SUN Lin-Lin², WANG Zhen-Xin²

1. College of Chemistry, Jilin University, Changchun 130023, China;
2. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2011-04-22 Online:2012-04-10 Published:2012-04-10
Supported by:
国家自然科学基金(批准号: 20675080)资助.

Abstract

Abstract: The transmembrane behavior of rich arginine(R) peptide modified gold nanoparticles was studied. The functionalization of the gold nanoparticles was achieved by the conjugation of transmembrane peptide RRRRRRRR(R₈) with peptide CALNN stabilized gold nanoparticle through the standard streptavidin-biotin chemistry. The transmembrane delivery of the model compound, fluorescein, was studied by confocal scanning laser microscope. The result suggests that the R₈ modified gold nanoparticles can be used as an excellent vector for transporting extracellular materials into cells with low cellular cytotoxicity.

Key words: Gold nanoparticle, Peptide, HeLa cell, Transmembrane delivery

CLC Number:

O657

TrendMD:

SHAN Hong-Yan, YU Bo, SUN Lin-Lin, WANG Zhen-Xin. Transmembrane Delivery of Rich Arginine Peptide Modified Gold Nanoparticles[J]. Chem. J. Chinese Universities, 2012, 33(04): 714.

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Transmembrane Delivery of Rich Arginine Peptide Modified Gold Nanoparticles

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