高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (6): 991.

• 研究论文 • 上一篇    下一篇

铜(Ⅱ)与2-羰基丙酸水杨酰腙配合物的合成、晶体结构和抑菌活性

何水样1, 曹文凯1, 陈军利1, 赵建设1, 史启祯1, 王汝贤2, 孙杰3   

  1. 1. 西北大学化学系, 陕西省物理无机化学重点实验室, 西安 710069;
    2. 西北农林科技大学植保学院, 杨凌 712100;
    3. 中国科学院上海有机化学研究所, 上海 200032
  • 收稿日期:2001-08-02 出版日期:2002-06-24 发布日期:2002-06-24
  • 通讯作者: 何水样(1946年出生),女,教授,从事配位化学研究.
  • 基金资助:

    陕西省自然科学基金(批准号:98H010);陕西省教育厅专项基金(批准号:98JK118)资助.

Synthesis, Crystal Structure and Antibacterial Activity of Copper(Ⅱ) Complexes with 2-oxo-Propionic Acid Salicyloyl Hydrazone

HE Shui-Yang1, CAO Wen-Kai1, CHEN Jun-Li1, ZHAO Jian-She1, SHI Qi-Zhen1   

  1. 1. Department of Chemistry, Northwest University and Shanxi Key Laboratory of Physico Inorganic Chemistry, Xi′an 710069, China;

    2. Institute of Plant Protection, Northwest Science and Technology University of Agriculture and Forestry, Yangling 712100, China;

    3. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • Received:2001-08-02 Online:2002-06-24 Published:2002-06-24

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被引次数

121

摘要： 以2-羰基丙酸水杨酰腙作为配体与五水硫酸铜进行反应,制得配合物Cu(C10H8N2O4)(H2O)2(1)和Cu(C10H8N2O4)(CH3OH)(H2O)(2)(C10H8N2O42-为2-羰基丙酸水杨酰腙负离子),测试了配合物2的单晶结构.该单晶为墨绿色,属三斜晶系,P1空间群.晶胞参数a=0.7538(2)nm,b=1.1431(2)nm,c=0.7500(2)nm,α=93.26(2)o,β=94.46(2)o,γ=94.39(2)o,V=0.6411(2)nm3,μ=1.731mm-1,Z=2,Dc=1.792g/cm3,F(000)=342.00,R=0.035,wR=0.048,GOF=1.78.在配合物2内,2-羰基丙酸水杨酰腙负离子中的2个氧原子和1个氮原子、甲醇中的氧原子以及配位水中的氧原子与铜原子配位,形成四方锥结构,其中来自甲醇的配位氧原子位于锥顶;此晶体为外消旋化合物,晶体中存在对映异构体,两者通过氢键连接,形成二聚体,成对出现在晶胞中.根据元素分析、红外和紫外光谱推测配合物1与2的结构相似;抑菌试验结果表明,配合物1对辣椒疫霉菌和烟草赤星菌分别有100%和66.02%的抑制作用.

关键词: 铜(Ⅱ)配合物, 2-羰基丙酸水杨酰腙, 晶体结构, 抑菌活性

Abstract: Two copper(Ⅱ) complexes with 2-oxo-propionic acid salicyloyl hydrazone, Cu(C10 H8N2O4)·(H2O)2 (1) and Cu(C10 H8N2O4)(CH3OH)(H2O) (2) (C10 H8N2O42- is the dinegative ion of 2-oxo-propionic acid salicyloyl hydrazone), have been synthesized. Bottle green prismatic crystals of complex 2 were obtained, and the crystal structure was determined by single crystal X-ray diffraction. Complex 2 crystallized in the triclinic space group P1 with a=0.7538(2) nm, b=1.1431(2) nm, c=0.7500(2) nm, a=93.26(2)o, β-=94.46(2)o, γ =94.39(2)o, V=0.6411(2) nm3, μ =1.731 mm-1, Z=2, Dc=1.792 g/cm3, F(000)=342.00, GOF=1.78, R=0.035, wR=0.048 for 2630 observed reflections [ I>3.00σ(I)] out of 2946 unique reflections. In complex 2, Cu atom is square pyramidally coordinated by two Oatoms and one Natom of tridentate C10 H8N2O42- ligand, one Oatom of methanol molecule and one Oatom of water molecule with the Oatom of methanol molecule locating at the apical position. The crystal of complex 2 is a racemic compound, included a couple of enantiomers. The couples of enantiomers occur in the crystal of complex 2 in dimer bonding with two hydrogen bonds. According to elemental analyse and IR, the structure of complex 1 is supposed to be similar to that of complex 2. The results of biological activity tests show that complex 1 has 100% and 66.02% of bacteriostastic activity for phytophthora capsic and alternaria alternaea, respectively.

Key words: Copper(Ⅱ) complex, 2-Oxo-propionic acid salicyloyl hydrazone, Crystal structure, Autibacterialc activity

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