高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (5): 815.

• 论文 • 上一篇    下一篇

一种新颖的抗血栓材料的研究

应锡璋1, 王蓓蓓1, 姚诗凯1, 朱建国1, 朱立红2, 邵慧珍2, 马挺3, 姚洪熹4   

  1. 1. 上海第二医科大学基础医学院, 上海 200025;
    2. 上海血液研究所, 瑞金医院;
    3. 上海交通大学应用化学系;
    4. 上海交通大学理化实验中心
  • 收稿日期:1995-05-10 出版日期:1996-05-24 发布日期:1996-05-24
  • 通讯作者: 应锡璋,男,49岁,硕士,副研究员.
  • 作者简介:应锡璋,男,49岁,硕士,副研究员.
  • 基金资助:

    国家自然科学基金

The Study on a Novel Anticoagulative Material

YING Xi-Zhang1, WANG Bei-Bei1, YAO Shi-Kai1, ZHU Jian-Guo1, ZHU Li-Hong2, SHAO Hui-Zhen2, MA Ting3, YAO Hong-Xi4   

  1. 1. Basic Medical College, Shanghai Second Medical University, Shanghai 200025;
    2. Shanghai Institute of Hematology, Ruijin Hospital;
    3. Department of Applied Chemistry, Shanghai Jiao-Tong University;
    4. Physicochemical Laboratory Center, Shanghai Jiao-Tong University
  • Received:1995-05-10 Online:1996-05-24 Published:1996-05-24

PDF (PC)

被引次数

16

摘要： 聚氨酯和肝素经低温等离子体表面处理后,直接以共价键形式结合,在聚氨酯管的内壁生成了光滑的聚氨酯-肝素接枝共聚体。经全血凝固时间的检测,新鲜人血注入聚氨酯-肝素接枝管后搁置5昼夜,电镜检查其管壁未见血栓痕迹。凝血酶时间等检测表明,接枝管起着抗血液凝固的功效,且肝素不脱落。经红外光谱测试,差谱中的新吸收谱带1165和1339cm-1表明聚氨酯和肝素分子之间生成了新共价键N-SO2或O-SO2的SO2官能团的对称和反对称伸缩振动。

关键词: 低温等离子体, 聚氨酯-肝素接枝共聚体, 抗凝血性

Abstract: The heparin has been grafted directly on the surface of polyurethane with the help of hypothermia plasma treatment.The smooth polyurethane-heparin graft copolymer is deeped in the inside tube wall.By dotting time (CT)test fresh human blood is injected to the polyurethane-heparin graft tube,after 5 days and nights there isn' t any thrombin the inside tube wall.By kaolin partial thomboplastin time (KPTT), prothrombin time(PT)and thrombin time (TT)tests to these polyurethane-heparin graft tubes, the results are that,this novel graft tube has anticoagulation visibly and there isn't falling free heparin from the tube wall, In infrared spectrum peaks 1165 cm-1 and 1339 cm-1 are symmetric and antisymmetric stretch vibrations of SO2 group in new covalent bond N—SO2 or O-SO2.

Key words: Hypothermia plasma, Polyurethane-heparin graft copolymer, Anticoagulation

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