高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (12): 1893.

• 研究简报 • 上一篇    下一篇

强镇痛活性生物碱Epibatidine及其类似物的构效关系研究

徐建平1, 何东1, 王志中2, 沈家骢1, 高连勋3, 宋雅茹4   

  1. 1. 吉林大学化学系, 长春, 130023;
    2. 吉林大学理论化学研究所, 长春, 130023;
    3. 中国科学院长春应用化学研究所;
    4. 北京师范大学化学系
  • 收稿日期:1995-11-29 出版日期:1996-12-24 发布日期:1996-12-24
  • 通讯作者: 徐建平,男,31岁,博士,讲师.
  • 作者简介:徐建平,男,31岁,博士,讲师.
  • 基金资助:

    吉林省科学技术委员会青年基金

Studies on Structure-Activity Relationship of Epibatidine and Its Analogues

XU Jian-Ping1, HE Dong1, WANG Zhi-Zhong2, SHEN Jia-Cong1, GAO Lian-Xun3, SONG Ya-Ru4   

  1. 1. Department of Chemistry, Jilin University, Changchun, 130023;
    2. Institute Theoretical Chemistry, Jilin University, Changchun, 130023;
    3. Changchun Institute of Applied Chemistry;
    4. Department of Chemistry, Beijing Normal University
  • Received:1995-11-29 Online:1996-12-24 Published:1996-12-24

PDF (PC)

被引次数

2

关键词: Epibatidine, AM1, 生物碱, 结构活性关系

Abstract: This paper reported the investigation of structure-activity relationship of the strong analgetic alkaloid epibatidine and it's analogues by using AMImethod. Some information was given according to the calculation results of HOMO electron density and electron charge distribution etc.It is also indicated that the biophores were the bridge nitrogen and exo-pyridine moiety of these alkaloids.

Key words: Epibatidine, AMl, Alkaloid, Structure-activity relationship

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