高等学校化学学报

高等学校化学学报

• 研究快报 • 上一篇    下一篇

新型微盘传感器的研制及用于单细胞释放NO监测

杜富滢, 黄卫华, 吴文展, 王宗礼, 程介克   

  1. 武汉大学化学与分子科学学院, 武汉 430072
  • 收稿日期:2007-03-22 修回日期:1900-01-01 出版日期:2007-06-10 发布日期:2007-06-10
  • 通讯作者: 程介克

Fabrication of Novel Microdisk Sensor and Its Application to Monitoring Nitric Oxide Release from Single Cell

DU Fu-Ying, HUANG Wei-Hua*, WU Wen-Zhan, WANG Zong-Li, CHENG Jie-Ke*   

  1. College of Chemistry & Molecular Science, Wuhan University, Wuhan 430072, China
  • Received:2007-03-22 Revised:1900-01-01 Online:2007-06-10 Published:2007-06-10
  • Contact: CHENG Jie-Ke

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被引次数

6

摘要： 首次提出了一种新型碳纳米管修饰方法, 采用精确的空间操纵, 在碳纤维微盘电极盘面上修饰单壁碳纳米管, 得到新型高灵敏的NO微盘传感器, 与未修饰电极相比, 灵敏度提高10倍, NO检出限达到4.3 nmol/L, 已被成功地应用于实时动态监测单个人脐静脉内皮细胞中NO的释放.

关键词: 一氧化氮, 超微盘电极, 碳纳米管, 单细胞释放

Abstract: A novel nitrogen oxide(NO) sensor fabricated by modifying the only planar surface of a carbon fiber microdisk electrode(CFMDE) with single-walled carbon nanotubes(SWNTs) and Nafion membrane was reported for the first time. The modification of SWNTs dramatically improves the sensitivity of CFMDEs and the detection limit of NO was 4.3 nmol/L. The sensor was successfully applied to the measurement of NO released from single isolated human umbilical vein endothelial cells.

Key words: Nitric oxide, Ultramicrodisk electrode, Carbon nanotubes, Single cell release

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