高等学校化学学报

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (4): 787.

• 研究简报 • 上一篇    下一篇

膜表面具有2-羟基-3-氯丙基或环氧丙基的对pH和离子强度敏感的新型磷酸酯囊泡

宋溪明1, 张国林2, 吴秋华1, 刘凤岐3, 田鹏1, 刘振荣1, 张向东1, 张锋1, 王君1, 刘祁涛1   

  1. 1. 辽宁大学化学科学与工程学院, 沈阳 110036;
    2. 北京大学化学与分子工程学院, 北京 100871;
    3. 吉林大学化学学院, 长春 130023
  • 收稿日期:2003-03-20 出版日期:2004-04-24 发布日期:2004-04-24
  • 通讯作者: 宋溪明(1957年出生),男,博士,教授,从事分子聚集体化学和生物无机化学研究.E-mail:xmsong@lnu.edu.cn E-mail:xmsong@lnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29571015);辽宁省青年科技人才培养基金(批准号:973007)资助

Novel pH and Ionic Strength-sensitive Vesicles Composed of Alkyl Phosphates with 2-Hydroxy-3-chloropropyl or Epoxy Propyl on Their Membrane Surface

SONG Xi-Ming1, ZHANG Guo-Lin2, WU Qiu-Hua1, LIU Feng-Qi3, TIAN Peng1, LIU Zhen-Rong1, ZHANG Xiang-Dong1, ZHANG Feng1, WANG Jun1, LIU Qi-Tao1   

  1. 1. School of Chemical Science and Engineering, Liaoning University, Shenyang 110036, China;
    2. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
    3. College of Chemistry, Jilin University, Changchun 130023, China
  • Received:2003-03-20 Online:2004-04-24 Published:2004-04-24

PDF (PC)

被引次数

7

关键词: 泡囊, 磷酸酯, 2-羟基-3-氯丙基, 环氧基

Abstract: Amphiphilic alkyl (dodecyl and hexadecyl)-2-hydroxy-3-chloropropyl phosphates (C12 - and C16 -AHCP) were synthesized, and then alkyl glycidyl phosphates (C12 - and C16 -AGP) were quantitatively obtained by the treatment of AHCP with NaOH in order to prepare a novel vesicle which has reactive and polymerizable epoxy group on its membrane surface. The bilayer vesicles were formed by ultrasonication of aqueous dispersion of C16 -AHCP or C16 -AGP, but the vesicles composed of C12 -AHCP and C12 -AGP were not obtained by the same treatment. Both of C16 -AHCP and C16 -AGP bilayer vesicles are only stable at pH5—10 or the ionic strength below 0.15. The gel-filtration chromatography and the UV-Vis absorption spectroscopic studies on Co(Ⅱ) tetrakis(propyloxycarbonyl)phthalocyanine as a lipophilic probe indicated that the phthalocyanine was effectively incorporated into the C16 -AHCP bilayer membranes and predominantly present in a monomeric state in the membranes, which is much different from its leading diameric state in SDS micelle and ethanol.

Key words: Vesicle, Phosphate, 2-Hydroxy-3-chloropropyl, Epoxy

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