高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (6): 1555.doi: 10.7503/cjcu20121131

• 高分子化学 • 上一篇    下一篇

新型不饱和聚磷酸酯的合成、表征及性能

王丹1, 白银娟1, 何贵强1, 张宇澄1, 宫永宽1, 张世平1,2   

  1. 1. 西北大学化学与材料科学学院, 合成与天然功能分子化学教育部重点实验室, 西安 710069;
    2. 西北大学生命科学学院, 西安 710069
  • 收稿日期:2012-12-14 出版日期:2013-06-10 发布日期:2013-05-09
  • 通讯作者: 张世平,女,博士,副教授,主要从事脂肪族聚酯的仿生改性研究.E-mail:zhangshp413@163.com E-mail:zhangshp413@163.com
  • 基金资助:

    国家自然科学基金(批准号: 21004048)、 中国博士后基金(批准号: 2012M512021)和陕西省教育厅项目(批准号: 2010JK886)资助.

Synthesis, Characterization and Properties of a Novel Unsaturated Polyphosphoester

WANG Dan1, BAI Yin-Juan1, HE Gui-Qiang1, ZHANG Yu-Cheng1, GONG Yong-Kuan1, ZHANG Shi-Ping1,2   

  1. 1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, China;
    2. College of Life Sciences, Northwest University, Xi’an 710069, China
  • Received:2012-12-14 Online:2013-06-10 Published:2013-05-09

PDF (PC)

被引次数

4

摘要：

通过溶液聚合制备了一种新型不饱和聚磷酸酯(Polymer Ⅰ), 经季铵化得到了侧基含季铵基的不饱和聚磷酸酯(PolymerⅡ). 对聚合物的结构和热性能进行了表征. 研究了PolymerⅡ与聚丁二酸丁二醇酯(PBS)的共混片基(Polymer Ⅱ的质量分数分别为5%, 10%和20%)在pH=7.4的磷酸缓冲溶液中的溶胀和降解性能. 结果表明, 以纯三甲胺为季铵化试剂, 在V(氯仿): V(异丙醇): V(DMF)=3: 5: 5的混合溶剂中, 于60℃反应24 h可得到季铵化率高达48%的PolymerⅡ. 在PBS中PolymerⅡ的含量越多, 达到溶胀平衡时, 共混片基的溶胀率越高, 越容易降解. 磷酸酯的引入使聚合物的熔点(Tm)和热稳定性(Td)降低.

关键词: 不饱和聚磷酸酯, 富马酸丁二醇酯, 生物降解, 溶胀性能

Abstract:

A new biodegradable and biocompatible unsaturated polyphosphoester bearing quaternary ammo-nium pendent groups was synthesized and characterized by 1H NMR, FTIR, gel permeation chromatography (GPC) and elemental analysis. Physical properties of the synthesized polymers were also characterized by means of thermal analysis, in vitro degradation and swelling behavior. The experimental evidence demonstrated that the introduction of quaternary ammonium pendent groups reduced the melting point and the decomposition temperature of polyphosphoester. The experiments of in vitro degradation and swelling behavior revealed that the more polyphosphoester in the polymer tablets, the faster degradation rates and the higher swelling ratio.

Key words: Unsaturated polyphosphoester, Butylene fumarate, Biodegradation, Swelling behavior

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