高等学校化学学报

高等学校化学学报 ›› 2009, Vol. 30 ›› Issue (5): 923.

• 研究论文 • 上一篇    下一篇

新型β,β-桥连双卟啉的合成及其光敏活性研究

黄齐茂, 肖欣, 潘志权, 李志远, 邓鹏星, 章颖   

  1. 武汉工程大学绿色化工过程省部共建教育部重点实验室, 武汉 430073
  • 收稿日期:2008-10-06 出版日期:2009-05-10 发布日期:2009-05-10
  • 通讯作者: 潘志权, 男, 博士, 教授, 博士生导师, 主要从事大环及配位化学研究, E-mail: zhiqpan@163.com
  • 基金资助:

    国家自然科学基金(批准号: 20471045)和湖北省自然科学基金杰出人才项目(批准号: 2008CDB072)资助.

Synthesis of Novel β,β-Bridged Porphyrin Dimers and Investigation of Their Photosensitive Activity

HUANG Qi-Mao, XIAO Xin, PAN Zhi-Quan*, LI Zhi-Yuan, DENG Peng-Xing, ZHANG Ying   

  1. Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China
  • Received:2008-10-06 Online:2009-05-10 Published:2009-05-10
  • Contact: PAN Zhi-Quan, E-mail: zhiqpan@163.com

PDF (PC)

摘要：

以1,6-二溴己烷为桥连试剂, 2-(1-羟基萘基)-5,10,15,20-四苯基卟啉及其Cu(Ⅱ), Ni(Ⅱ), Zn(Ⅱ)配合物为原料, 合成了4个新型β,β-桥连双卟啉. 以1,3-二苯基异苯并呋喃(DPBF)为猝灭剂, 测试了双卟啉及其Ni(Ⅱ), Zn(Ⅱ)配合物在光照条件下产生单线态氧的能力, 并研究了4个双卟啉化合物在光照和无光照条件下对pBR322质粒DNA的切割能力(用凝胶电泳)和对金黄色葡萄球菌(ATCC 25923)的光敏抑菌活性. 结果表明, 新型双卟啉光敏剂具有较好光敏活性, 产生的活性氧能有效杀灭金黄色葡萄球菌.

关键词: 双卟啉, pBR322质粒DNA, 抗菌, 光敏活性

Abstract:

Four novel β,β-bridged porphyrin dimers were designed and synthesized. The monomers are 2-(1-hydroxynaphthyl)-5,10,15,20-tetraphenylporphyrin or its Cu(Ⅱ), Ni(Ⅱ), Zn(Ⅱ) complexes. The abilities of singlet oxygen production for the porphyrin dimer and its Ni(Ⅱ), Zn(Ⅱ) complexes under photo irradiation were studied with DPBF as the quencher. The cleavage ability of pBR322 DNA(by gel electrophoresis) and antibacterial activity on Staphylococcus aureus(ATCC 25923) of the novel porphyrin dimers were tested under photo irradiation and in dark. The results show that porphyrin dimers exhibit high photocytotoxicity against Staphylococcus aureus.

Key words: Porphyrin dimer, pBR322 DNA, Antibacterial, Photosensitive activity

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