高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (11): 2470.doi: 10.7503/cjcu20130580

• 研究论文: 无机化学 • 上一篇    下一篇

Zn-MOF模板法制备ZnO/C/SNTs及其药物缓释性能

李宗群, 汪艾, 郭春燕, 胡文娜, 邰燕芳   

  1. 蚌埠学院应用化学与环境工程系, 蚌埠 233000
  • 收稿日期:2013-06-24 出版日期:2013-11-10 发布日期:2013-09-17
  • 作者简介:李宗群,男,副教授,主要从事金属-有机骨架合成及性质研究,E-mail:bbxylzq@163.com
  • 基金资助:

    国家自然科学基金(批准号:20971001)和安徽省教育厅重点自然科学基金(批准号:KJ2012A193)资助.

Synthesis of ZnO/C/SNTs Using Zn-MOF as Template and Their Drug Delivery Ability

LI Zong-Qun, WANG Ai, GUO Chun-Yan, HU Wen-Na, TAI Yan-Fang   

  1. Department of Applied Chemistry and Environmental Engineering, Bengbu College, Bengbu 233000, China
  • Received:2013-06-24 Online:2013-11-10 Published:2013-09-17

摘要:

采用超声法一步合成了SiO2包覆金属-有机骨架[Zn6(OH)3(BTC)3(H2O)3] ·7H2O(Zn-MOF, BTC=1,3,5-均苯三羧酸根)纳米晶, 在N2保护下, 热解Zn-MOF@SiO2获得了ZnO/C/SNTs复合物, 进而与布洛芬(HIBU)反应合成药物组装体Zn(IBU)2/C/SNTs. 通过透射电子显微镜(TEM)、 傅里叶变换红外光谱仪(FTIR)、 高分辨透射电子显微镜(HRTEM)和X射线衍射仪(XRD)对样品的结构和形貌进行表征. 结果显示, Zn-MOF@SiO2呈棒状, 具有清晰的核/壳结构, 形貌单一, 分散性良好. 煅烧后SNTs结构稳定, 形貌基本不变. 载药实验表明, 药物组装体的载药量为752 mg/g, 并具有良好的pH响应性能.

关键词: 金属-有机骨架, 核/壳结构, 二氧化硅纳米管, 缓释

Abstract:

Nanocrystallines of metal-organic framework [Zn6(OH)3(BTC)3(H2O)3] ·7H2O(Zn-MOF, BTC=benzene-1,3,5-tricarboxylate) coated with SiO2 nanotubes(SNTs) were synthesized by a simple one-step ultrasonic route. ZnO/C/SNTs hybrid composites were produced by thermolysis of Zn-MOF/SNTs in N2 environments, then the drug assemblies of Zn(IBU)2/C/SNTs were synthesized by the reaction of ibuprofen(HIBU) and ZnO/C/SNTs. The morphology and structure of nanoparticle were characterized by transmission electron microscopy(TEM), high resolution transmission electron microscopy(HRTEM), Fourier transform infrared spectrometry(FTIR) and X-ray diffraction(XRD). The results show that the Zn-MOF/SNTs have clear core-shell structure with rod-like shape, same-sized and well-dispersed. The as-prepared SNTs have better structure stability and the morphologies remain unchangeable after calcination. The results demonstrated that the drug loading was about 752 mg/g, and the drug assemblies had an excellent pH responsive behavior.

Key words: Metal-organic framework, Core-shell structure, Silica nanotube, Sustained release

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