关键词: 大豆苷元;7,4′-二甲氧基异黄酮-3′-磺酸钠;7,4′-二甲氧基异黄酮-3′-磺酸铜;抗缺氧缺血活性, 大豆苷元, 7, 4'-二甲氧基异黄酮-3'-磺酸钠, 7, 4'-二甲氧基异黄酮-3'-磺酸铜, 抗缺氧缺血活性

Abstract: The water soluble derivatives of daidzein sodium 7,4'-bimethoxylisoflavone-3'-sulfonate(1) and copper(Ⅱ) 7,4'-bimethoxylisoflavone-3'-sulfonate(2) were synthesized and their structures were characterized by IR,NMR,ESI-MS and X-ray diffraction analyses.In the crystal structure of compound 1,each sodium ion is six-coordinated by oxygens from the methoxyl and suflo-group of 7,4'-bimethoxylisoflavone-3'-sulfonate and H₂O.Two adjacent sodium ions were bridged by the oxygen atoms from suflo-group and a six-membered ring is formed.The six-membered ring consists of two sodium ions,three oxygen atoms from two suflo-groups and a sulfur atom.The Na—O bonds of adjacent rings are paralleled with each other and form an one-dimensional zigzag sodium polyion chain along axis c of the unit cell. The sodium ions chains are also connected by the hydrogen bonds among coordination water molecules,between coordination water molecules and oxygen from suflo-group.The coordination interaction,hydrogen bonds and the electrostatic interaction between sodium ion and —SO^-₃ made compound 1 assemble supramolecular ion polymer with two-dimensional structure.The crystal of compound 2 consists of [Cu(H₂O)₆]²+,C₁7H₁3O₄SO^-₃ and H₂O.Cu(Ⅱ) is at the symmetry center of structure of compound 2 and octahedrally coordinated by six water molecule.[Cu(H₂O)₆]²+,C₁7H₁3O₄SO^-₃ and H₂O form several kinds of hydrogen bonds.The distance of 0.358 2 nm between anti-parallel isoflavone rings shows a π…π stacking interaction. The hydrogen bonds and π…π stacking interaction lead to supramolecular formation with three-dimensional network structure.The biological activities of resistance to hypoxia and anoxemia were tested,the results show that the biological activities of resistance to hypoxia and anoxemia of compounds 1 and 2 were better than that of daidzein.

Key words: Daidzein; Sodium 7,4′-bimethoxylisoflavone-3′-sulfonate; Copper(Ⅱ) 7,4′-bimethoxylisoflavone-3′-sulfonate;  Crystal structure; Resistance to hypoxia and anoxemia, Daidzein, Sodium 7,4'-bimethoxylisoflavone-3'-sulfonate, Copper(Ⅱ) 7,4'-bimethoxylisoflavone-3'-sulfonate, Crystal structure, Resistance to hypoxia and anoxemia