高等学校化学学报

高等学校化学学报

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新型N,N'-二(邻氧乙酸)苄叉丙二胺合铜(II)和镍(Ⅱ)及N-(邻氧乙酸)苄叉丙二胺合铜(Ⅱ)的合成、晶体结构及抑菌活性

王占良, 朱东升, 王荣顺   

  1. 东北师范大学化学学院, 长春 130024
  • 收稿日期:2007-10-16 修回日期:1900-01-01 出版日期:2008-05-10 发布日期:2008-05-10
  • 通讯作者: 王荣顺

Synthesis, Crystal Structure and Antibacterial Activity of Two Novel Complexes of N,N'-Bis(o-oxy-acetate)benzylpropylenediamine with Cu(Ⅱ) and Ni(Ⅱ) and a Complex N-(o-oxy-acetate)benzylpropylenediamine with Cu(Ⅱ)

WANG Zhan-Liang, ZHU Dong-Sheng, WANG Rong-Shun*   

  1. Faculty of Chemistry, Northeast Normal University, Changchun 130024, China
  • Received:2007-10-16 Revised:1900-01-01 Online:2008-05-10 Published:2008-05-10
  • Contact: WANG Rong-Shun

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摘要： 在乙醇和水的混合溶液中, 将N,N'-二(邻氧乙酸)苄叉丙二胺(1)与氯化铜反应, 获得配合物Cu(Ⅱ)L1·H2O·0.25CH3CH2OH(2)[L1=N,N'-二(邻氧乙酸)苄叉丙二胺]; 当将反应混合溶液的pH值调至8~9, 获得Cu(Ⅱ)ClL2·3H2O(3)[L2=N-(邻氧乙酸)苄叉丙二胺]; 将N,N'-二(邻氧乙酸)苄叉丙二胺(1)与氯化镍反应, 获得配合物Ni(Ⅱ)L1·2.75H2O(4). 用元素分析、1H NMR和IR谱等方法对所合成的化合物1和配合物2~4进行了表征, 并测定了配合物2~4的晶体结构. 在配合物2中, 铜原子为六配位[CuN2O4], 在配合物3中, 铜原子为六配位[CuN2O3Cl], 在配合物4中, 镍原子为六配位[NiN2O4], 三个配合物均为畸变八面体结构. 抑菌活性大小的顺序: 配合物3>配合物2>化合物1.

关键词: 邻氧乙酸苯甲醛, 铜(Ⅱ)配合物, 晶体结构, 抑菌活性

Abstract: Complex Cu(Ⅱ)L1·H2O·0.25CH3CH2OH(2)[L1=N,N'-bis(o-oxy-acetate) benzylpro-pylenediamine(1)] was synthesized via the reactions between compound 1 and Cu(Ⅱ) dichloride in the solvents of water and ethanol, and Cu(Ⅱ)ClL2·3H2O(3)[L2=N-(o-oxy-acetate) benzylpropylenediamine ] was prepared via the reaction between compound 1 and Cu(Ⅱ) dichloride in the solvents of water and ethanol(pH=8~9). Complex Ni(Ⅱ)L1·2.75H2O(4) was also synthesized by the reactions between the compounds 1 and Ni(Ⅱ) dichloride in water. Compounds 1—4 were characterized by elemental analysis, 1H NMR, FTIR spectroscopy and single crystal X-ray diffraction analysis. There are one molecule(hostmolecule), one water molecule(guestmolecule) and quarter ethanol molecule in one asymmetric unit of complex 2, the Cu(Ⅱ) atom exhibits a distorted octahedral geometry. There are one molecule(hostmolecule) and three water molecules in each unit of complex 3, the Cu(Ⅱ) atom exhibits a distorted octahedral geometry. In the asymmetric unit of complex 4, the Ni(Ⅱ) atom also exhibits a distorted octahedral geometry. Complexes 2 and 3 exhibit good antibacterial properties, while the antibacterial properties decrease in the following order: complex 3>complex 2> compound 1.

Key words: o-Oxy-acetate-benzaldehyde, Cu(Ⅱ) complex, Crystal structure, Antibacterial activity

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