复方板蓝根颗粒化学成分的质谱研究

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (6): 1137.

复方板蓝根颗粒化学成分的质谱研究

刘舒1,3, 闫峻2, 李惠琳1, 宋凤瑞1, 刘忠英2, 刘志强1, 刘淑莹1

1. 中国科学院长春应用化学研究所, 长春质谱中心, 长春 130022;
2. 吉林大学药学院, 长春 130021;
3. 中国科学院研究生院, 北京 100049

收稿日期:2009-10-26 出版日期:2010-06-10 发布日期:2010-06-10
通讯作者: 刘志强, 男, 博士, 研究员, 博士生导师, 主要从事天然药物化学和有机质谱学研究. E-mail: liuzq@ciac.jl.cn
基金资助:
国家科技支撑计划项目(批准号： 2006BAI08B03-02)资助.

Studies on Chemical Constituents of Compound Indigowoad Root Granule by Mass Spectrometry

LIU Shu1,3, YAN Jun2, LI Hui-Lin1, SONG Feng-Rui1, LIU Zhong-Ying2, LIU Zhi-Qiang1*, LIU Shu-Ying1

1. Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2. School of Pharmacy, Jilin University, Changchun 130021, China;
3. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

Received:2009-10-26 Online:2010-06-10 Published:2010-06-10
Contact: LIU Zhi-Qiang. E-mail: liuzq@ciac.jl.cn
Supported by:
国家科技支撑计划项目(批准号： 2006BAI08B03-02)资助.

摘要/Abstract

摘要：

利用电喷雾多级串联质谱(ESI-MSⁿ)和傅里叶变换离子回旋共振质谱(FT-ICR-MS)技术, 对复方板蓝根颗粒经溶剂萃取后的95%(体积分数)醇提和水提部位的化学成分进行了系统研究, 鉴定出多种氨基酸成分、糖及其衍生物、有机酸、氨基酸和单糖的梅拉德反应初级产物以及含硫化合物表告依春. 该方法灵敏快速, 适宜于中药提取物的化学成分分析.

关键词: 复方板蓝根; 化学成分; ESI-MSn; FT-ICR-MS

Abstract:

Muti-tandem electrospray ionization mass spectrometry(ESI-MSⁿ) and Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS) have been applied to analyse the chemical constituents from water and 95% ethanol extract of Compound Indigowoad Root Granule. A number of compounds were identified including amino acid, sugar and their derivatives, organic acid, primary products of the Maillard reaction of amino acid with monosaccharide and epigoitrin. This method is sensitive and rapid, suitable for analyzing the chemical composition of traditional Chinese medicine extract.

Key words: Compound Indigowoad Root; Chemical constituent; Muti-tandem electrospray ionization mass spectrometry(ESI-MSn); Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)

TrendMD:

刘舒1,3, 闫峻2, 李惠琳1, 宋凤瑞1, 刘忠英2, 刘志强1, 刘淑莹1. 复方板蓝根颗粒化学成分的质谱研究. 高等学校化学学报, 2010, 31(6): 1137.

LIU Shu1,3, YAN Jun2, LI Hui-Lin1, SONG Feng-Rui1, LIU Zhong-Ying2, LIU Zhi-Qian. Studies on Chemical Constituents of Compound Indigowoad Root Granule by Mass Spectrometry. Chem. J. Chinese Universities, 2010, 31(6): 1137.

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