高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (9): 1771.

• 研究快报 • 上一篇    下一篇

电活性可生物降解材料聚乳酸与苯胺五聚体嵌段共聚物的合成与表征

黄利红1,2, 胡军1,2, 庄秀丽1,2, 马嘉1,2, 陈学思1,2, 景遐斌1,2, 郭毅3, 李梦燕3, Peter I.Lelkes3, 危岩3   

  1. 1. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春130022;
    2. 中国科学院研究生院,北京100039;
    3. 爵硕大学化学系,PA19104,USA
  • 收稿日期:2005-06-27 出版日期:2005-09-10 发布日期:2005-09-10
  • 基金资助:

    国家自然科学基金(批准号:50273038,20274028);国家杰出青年基金(批准号:50425309)资助.

Synthesis and Characterization of Electro-active and Biodegradable Block Copolymer of Aniline Pentamer with Polylactide

HUANG Li-Hong1,2, HU Jun1,2, ZHUANG Xiu-Li1,2, MA Jia1,2, CHEN Xue-Si1,2, JING Xia-Bin1,2, GUO Yi3, LI Meng-Yan3, Peter I. Lelkes3, WEI Yen3   

  1. 1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
    2. The Graduate School of Chinese Academy of Sciences, Beijing 100039, China;
    3. Department of Chemistry, Drexel University, PA 19104, USA
  • Received:2005-06-27 Online:2005-09-10 Published:2005-09-10

PDF (PC)

被引次数

12

关键词: 聚乳酸, 苯胺齐聚物, 电活性, 可生物降解

Abstract: Every slight movement of human body, such as beat of heart, contract of muscles, thinking of brain, is associated with bioelectricity. In search for a neural conducting tissue engineering material which can {ideally} conduct bioelectrical signals in vivo, the block copolymer of polylactide(PLA) and aniline pentamera material which is electro-active, remarkably biocompatible and biodegradable, was designed and synthesized. The aniline pentamer is similar with polyaniline in electrical chemical properties, but more soluble than the latter. The copolymer is prepared by condensation polymerization between carboxyl-capped aniline pentamer and {dihydroxyl}-capped PLA, with N,N'-dicyclohexylcarbodiimide(DCC) as a condensing agent. The co-polymerization of aniline pentamer and PLA can not only reduce the toxicity of aniline pentamer, but also make the {material} easily to degrade and excrete from the body. These properties of the copolymer provide a favorable prospect in biomedical application in vivo. The synthesized material is investigated by FTIR, 1H NMR, UV, and cyclic voltammetric measurements.

Key words: Polylactide, Aniline pentamer, Electrical activity, Biodegradablility

中图分类号: 

TrendMD: