高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (10): 1952-1956.

• 研究论文 • 上一篇    下一篇

可注射性骨组织工程支架材料不饱和聚磷酸酯的合成

邱进俊1,2, 刘承美1, 胡芬1, 郭晓东3, 郑启新2,3   

  1. 1. 华中科技大学化学系;
    2. 华中科技大学生命科学与技术学院;
    3. 华中科技大学同济医学院附属协和医院骨科,武汉430074
  • 收稿日期:2004-10-12 出版日期:2005-10-10 发布日期:2005-10-10
  • 基金资助:

    国家自然科学基金(批准号:20374022);华中科技大学医工医理交叉基金资助.

Synthesis of Unsaturated Polyphosphoesteran Injectable Bone Tissue Engineering Scaffold Material

QIU Jin-Jun1,2, LIU Cheng-Mei1, HU Fen1, GUO Xiao-Dong3, ZHENG Qi-Xin2,3   

  1. 1. Department of Chemistry,Huazhong University of Science and Technology;
    2. College of Life Science and Technology,Huazhong University of Science and Technology;
    3. Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,China
  • Received:2004-10-12 Online:2005-10-10 Published:2005-10-10

摘要: 以富马酸、1,2-丙二醇和三氯氧磷为起始原料,合成了主链重复结构单元中含不饱和双键的聚磷酸酯.FTIR及NMR研究表明.不饱和聚磷酸酯(UPPE)主链结构中含有富马酸二(1,2-丙二醇)酯(BPGF)的三种异构体.利用GPC研究了反应时间对聚合反应的影响,结果表明,延长反应时间有利于提高分子量,聚合物趋向于单分散性.反应18 h后,聚合物重均分子量达到5 956 g/mol,分散度为1.12.通过测定UPPE与N-乙烯基吡咯烷酮(NVP)的交联温度曲线,确定交联反应最高温度为41.14-82.30℃,固化时间在1.95-10.28 m in之间.

关键词: 不饱和聚磷酸酯, 富马酸二(1, 2-丙二醇)酯, 生物高分子, 骨组织工程支架材料

Abstract: Unsaturated polyphosphoester(UPPE) containing unsaturated olefinic bonds in repeat units was synthesized by fumaric acid,1,2-propylene glycol and phosphorous oxytrichloride as the initiation materials.Three kinds of isomers of bis(1,2-propyleneglycol) fumarate were detected in main chain of UPPE by FTIR and NMR.The effect of reaction time on condensation polymerization reaction was investigated with GPC.High and uniform molecular weight of polymer can be obtained by extending polymerization reaction time.The molecular weight is 5 956 g/mol and the polymer dispersion degree is 1.12 after refluxing for 18 h.The temperature curve of UPPE crosslinked with N-vinyl pyrrolidone indicated that the maximum temperature is from 41.14 to 82.30 ℃,and the setting time is between 1.95 min and 10.28 min.

Key words: Unsaturated polyphosphoester, Bis(1,2-propyleneglycol) fumarate, Biomacromolecules, Bone tissue engineering soaffold material

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