高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (12): 2000.

• 研究论文 • 上一篇    下一篇

抗癌药物柔红霉素的光谱电化学研究

屈海云, 程圭芳, 彭惠琦, 何品刚, 方禹之   

  1. 华东师范大学化学系, 上海 200062
  • 收稿日期:2000-11-16 出版日期:2001-12-24 发布日期:2001-12-24
  • 通讯作者: 方禹之(1931年出生),男,教授,博士生导师,从事电分析化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29975010)资助

Spectroelectrochemistry Studies of Antitumor Antibiotics Daunomycin

QU HaiYun, CHENG GuiFang, PENG HuiQi, HE PinGang, FANG YuZhi   

  1. Department of Chemistry, East China Normal University, Shanghai 200062, China
  • Received:2000-11-16 Online:2001-12-24 Published:2001-12-24

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被引次数

36

摘要： 采用现场光谱电化学技术,结合循环伏安和红外光谱等手段,研究了柔红霉素的电极过程,并提出了可能的还原机理.结果表明,柔红霉素的还原途径与其浓度存在一定的联系:稀溶液的还原经历一ECE过程——得到两个电子还原为柔红霉氢醌后,发生化学反应脱去7位上的糖基侧链,得到的7-去氧柔红霉醌继续被还原,生成的自由基中间体可发生歧化反应或通过分子间缔合而稳定;当溶液浓度较大时,柔红霉素分子在得到一电子生成半醌自由基中间体后,以其双分子缔合物的形式稳定存在.

关键词: 蒽环类药物, 柔红霉素, 循环伏安, 光谱电化学

Abstract: The electrode process of antitumor daunomycin has been investigated by using in situ spectroelectrochemical techniques, with the aid of cyclic voltammetry and infrared spectrophotometry. Possible mechanisms of its reduction processes have been discussed where the concentration makes a critical effect. When the DRNconcentration is low, two successive one electron reduction steps are demonstrated, which was followed by an aglycon elimination reaction, and then, the product 7 deoxydaunomycinone received one electron to form 7 deoxysemidaunomycione free radical, such radicals can disproportionate or associate easily. But if high, only one electron reduction happened to get the corresponding semiquinone radicals, which can also associate rapidly.

Key words: Anthracycline antibiotics, Daunomycin, Cyclic voltammetry, Spectroelectrochemistry

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