高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (5): 809.

• 论文 • 上一篇    下一篇

交联壳聚糖膜的制备及其性能的研究

郑化, 杜予民, 余家会, 肖玲   

  1. 武汉大学环境科学系, 武汉 430072
  • 收稿日期:1999-08-05 出版日期:2000-05-24 发布日期:2000-05-24
  • 通讯作者: 杜予民(1937年出生),男,教授,博士生导师,主要从事再生资源化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29977014);上海中金集团公司资助

The Properties and Preparation of Crosslinked Chitosan Films

ZHENG Hua, DU Yu-Min, YU Jia-Hui, XIAO Ling   

  1. Department of Environmental Science, Wuhan University, Wuhan 430072, China
  • Received:1999-08-05 Online:2000-05-24 Published:2000-05-24

摘要: 用环氧氯丙烷成功地制备出交联壳聚糖膜。用FTIR,XRD和SEM方法表征其结构,并测试了其力学性能。结果表明,壳聚糖在低温下只有氨基参与交联反应,反应温度高于40℃时,羟基才发生反应;环氧氯丙烷的交联作用显着提高了壳聚糖膜的抗张强度,并有效地降低了溶菌酶对其降解速率;该交联膜有望用作可控降解的生物医用材料。

关键词: 壳聚糖, 环氧氯丙烷, 交联壳聚糖膜, 力学性能, 溶菌酶降解

Abstract: The crosslinked chitosan films were prepared with epichlorohydrin as a crosslinking agent, and characterized by FTIR, X-ray diffraction and SEM. Their mechanical properties were measured. The structure analysis indicated that at low temperature, the crosslinking reaction only occurred between -NH2 group of chitosan and epichlorohydrin. When the temperature was above 40 ℃, -OHgroup of chitosan reacted with epichlorohydrin. The results from SEMand measurement of mechanical properties showed that the tensile strength of the crosslinked films was considerably improved, and the rate of degradation of crosslinked films by lysozyme was reduced. The new crosslinked chitosan films are expected to be used as controllable degradation biomaterials.

Key words: Chitosan, Epichlorohydrin, Crosslinked chitosan film, Mechanical properties, Lysozyme degradation

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