高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (5): 729.

• 研究简报 • 上一篇    下一篇

Didemnaketal A类似物的合成研究──C1-C7中间体的合成

贾彦兴, 王平珍, 吴滨, 涂永强   

  1. 兰州大学化学系, 应用有机化学国家重点实验室, 兰州 730000
  • 收稿日期:1999-05-25 出版日期:2000-05-24 发布日期:2000-05-24
  • 通讯作者: 涂永强(1958年出生),男,博士,教授,博士生导师,从事生物有机化学研究.
  • 基金资助:

    国家教委博士点专项基金(批准号:96073006);教育部跨世纪人才基金;国家杰出青年基金(批准号:29925205)

Synthetic Studies of HIV-active Didemnaketal A Analogue ──Synthesis of a C1-C7 Fragment

JIA Yan-Xing, WANG Ping-Zhen, WU Bin, TU Yong-Qiang   

  1. Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:1999-05-25 Online:2000-05-24 Published:2000-05-24

关键词: 螺环缩酮, 中间体, 手性合成

Abstract: AC1-C7 fragment of the HIV-active Didemnaketal Aanalogue was synthesized from (R)-pulegone through 12 steps. Two new chiral centers, C3, C4 were successfully constructed by the steric induction in this approach and the aldehyde was selectively reduced.

Key words: Spiroketal, Intermediated Chiral synthesis

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