高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (9): 1416.

• 论文 • 上一篇    下一篇

手性Schiff Base-Ti(OR)4配合物催化醛的不对称硅腈化反应

冯小明, 龚流柱, 胡文浩, 李智, 潘卫东, 宓爱巧, 蒋耀忠   

  1. 中国科学院成都有机化学研究所不对称合成联合开放实验室, 成都, 610041
  • 收稿日期:1997-07-12 出版日期:1998-09-24 发布日期:1998-09-24
  • 通讯作者: 蒋耀忠
  • 作者简介:冯小明,男,33岁,博士,研究员.
  • 基金资助:

    国家自然科学基金(批准号:29602007)资助课题.

Chiral Schiff Base Ti(OR)4 Complexes Catalyzed Asymmetric Trimethylsilylcyanation of Aldehydes

FENG Xiao-Ming, GONG Liu-Zhu, HU Wen-Hao, LI Zhi, PAN Wei-Dong, MI Ai-Qiao, JIANG Yao-Zhong   

  1. Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041
  • Received:1997-07-12 Online:1998-09-24 Published:1998-09-24

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摘要： 设计合成了新型手性Salen-Ti(OR)4配合物催化剂,用其催化一系列醛的不对称硅腈化反应,得到了e.e.值为22.4%～87.1%的氰醇.催化剂中抗衡离子的Lewis碱强烈地影响催化活性,但对反应的对映选择性影响很小,并探讨了其不对称催化反应机理.

关键词: Schiff, base-Ti(OR)4配合物, 抗衡离子, 催化不对称硅腈化反应

Abstract: Aseries of new chiral catalysts of Salen-Ti(OR)4 complexes were synthesized, which were found to be efficient catalysts for the enantioselective silylcyanation of aldehydes. The enantioselectivities of 22.4%-87.1% were obtained by using chiral Salen Ti(OR)4 complexes as catalyst. The reaction mechanism was proposed and justified by experiments.

Key words: Schiff base-Ti(OR)4 complexes, Counter-ion, Catalytic asymmetric silylcyanation reaction

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