高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (11): 1899.

• 研究简报 • 上一篇    

聚苯乙烯-g-(十八烷基聚氧乙烯)阻抗血小板粘附的研究

计剑, 孙永红, 仝凤芹, 邱永兴, 封麟先   

  1. 浙江大学高分子科学与材料研究所, 杭州 310027
  • 收稿日期:1996-07-10 出版日期:1997-11-24 发布日期:1997-11-24
  • 通讯作者: 计剑, 男, 26岁, 博士研究生
  • 作者简介:计剑, 男, 26岁, 博士研究生.
  • 基金资助:

    国家自然科学基金

Studies on Platelet-Resistance of Amphiphilic Polystyrenegraft-ω-stearyl-poly(ethylene oxide)

JI Jian, SUn Yong-Hog, Tong Feng-Oin, QIU Yong-Xing, FENG Lin-Xian   

  1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027
  • Received:1996-07-10 Online:1997-11-24 Published:1997-11-24

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被引次数

23

关键词: 两亲接枝共聚物, 血液相容性, 血小板粘附, 蛋白质吸附

Abstract: The platelet adhesion and protein(Fibrinogen and albumin) adsorption ontoamphiphilic polystyrene-graft-poly(ethylene oxide) (PS-g-PEO) and polystyrene-graft -ω-stearyl-poly(ethyleneoxide) (PS-G-SPEO) were investigated.It was found that the plateletadhesion on PS-g-SPEOwas lower than that on PS-g-PEO.The PS-g-SPEOsurface shows apreference for Albumin, while the PS-g-PEOsurface absorbed Fibrinogen selectivelyu.Twoeffects of stearyl end group on PS-g-SPEOsurface: (1) the lower surface free energe leadsto SPEOenrich at surface; (2) the stearyl end group absorbed albumin selectively, seems tocontribute to resistant the platelet adhesion.So the polymer surface modificed by both stearylgroup and poly(ethylene oxide) chain may be a new ideal way to improve material's bloodcompatibility.

Key words: Amphiphilic copolymer, Blood, compatilility, Platelet adhesion, Protein adsorption

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