高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (8): 1231.

• 论文 • 上一篇    下一篇

1-芳胺羰基-3-苄硫基-4-乙氧羰基(或氰基)-5-氨基吡唑的合成及生物活性

陆荣健, 杨华铮, 赵国锋, 刘华银   

  1. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津 300071
  • 收稿日期:1995-08-18 出版日期:1996-08-24 发布日期:1996-08-24
  • 通讯作者: 杨华铮
  • 作者简介:陆荣健,男,33岁,博士,副教授.
  • 基金资助:

    国家自然科学基金;天津市青年科学基金

Synthesis of 1-Arylaminocarbonyl-3-benzylthio-4-carbethoxy(or cyano)-5-aminopyrazole

LU Rong-Jian, YANG Hua-Zheng, ZHAO Guo-Feng, LIU Hua-Yin   

  1. Institute of Elemento-Organic Chemistry, National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1995-08-18 Online:1996-08-24 Published:1996-08-24

PDF (PC)

被引次数

4

摘要： 利用5-氨基-4-乙氧羰基(或氰基)-3-苄硫基吡唑与异氰酸酯的加成反应合成了一系列1-芳胺羰基-3-苄硫基-4-乙氧羰基(或氰基)-5-氨基吡唑。利用分子力学计算,解释了1HNMR谱中的取代基效应。生物活性测定结果表明部分化合物具有良好的除草活性。

关键词: 吡唑衍生物, 分子力学, 取代基效应

Abstract: 1-Arylaminocarbonyl-3-benzylthio-4-carbethoxy(or cyano)-5-aminopyrazoles(3)were synthesized by the reaction of the 5-amino-3-benzylthio-4-carbethoxy(or cyano) pyrazole with the aryl isocyanate.It was found that there were great influence of the property and position of substituents X,Yon the chemical shift of H-(N2) in1H NMRspectra.By means of molecular mechanics calculations, the substituent effect on the chemical shift of H-(N2) was rationalized.The preliminary bioassay shows that some compounds have herbicidal activities.

Key words: Pyrazole derivatives, Molecular mechanics, Substituent effect

TrendMD: