关键词: (R)-2-硫代四氢噻唑-4-羧酸乙酯, N-3-(2-氧代环烷基)丙酰-2-硫代四氢噻唑-4-羧酸乙酯, 环合反应, &alpha, -苯乙胺

Abstract: he equimolar reaction of 3-(2-oxocyclohexyl)propionic acid or 3-(2-oxocy-clopentyl) propionic acid and(R)-2-thioxothiazolidine-4-carboxyli ethyl ester (1)with N-methyl-2-chloropyridium salt in the presence of triethylamine produced the corresponding op-tically active N-3-(2-oxocycloalkyl) propionyl-2-thioxothiazolidine-4-carboxylic ethyl ester(2_a) and N-3-(2-oxocyclopentyl)propionyl-2-thioazolidine-4-carboxylic ethyl ester(2_b).When the molar ratio of 3-(2-oxocyclohexyl)-propionic acid to compounds 1 is 2:1,2_a andS-excess 3-(2-oxocyclohexyl)propionic acid were obtained.When 2_a and 2_b react withracemic a-phenylethylamine(molar ratio 1:2),the photoactive compound N-3-(2-oxocyclo-hexyl)propionyl-α-phenylethylaine(5_a)or N-3-(2-oxocyclopentyl)propionyl-α-phenylethyla-mine(5_b)were obtained.

Key words: (R)-2-Thioxothiazolidine-4-carboxylic ethyl ester, N-3-(2-Oxocycloalkyl)propi-onyl-2-thioxothiazolidine-4-carboxylic ethyl ester, Cyclization, α-Phenylethylamine