高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (1): 24.

• 研究简报 • 上一篇    下一篇

EDDS与THEC的钆(Ⅲ)配合物的合成及其对水质子的弛豫性能研究

吕正荣1, 卓仁禧1, 尹超1, 周建威2   

  1. 1. 武汉大学化学系, 武汉 430072;
    2. 中国科学院武汉物理研究所
  • 收稿日期:1995-01-11 出版日期:1996-01-24 发布日期:1996-01-24
  • 通讯作者: 卓仁禧
  • 作者简介:吕正荣,男. 32岁,博士,教授.
  • 基金资助:

    国家“863”计划;国家教育委员会博士点基金

Synthesis and Proton Relaxivity of Gd-EDDS and Gd-EDDS and Gd-THEC

LU Zheng-Rong1, ZHUO Ren-Xi1, YIN Chao1, ZHOU Jian-Wei2   

  1. 1. Department of Chemistry, Wuhan University, Wuhan 430072;
    2. Wuhan Institute of Physics, Chinese Academy of Sciences
  • Received:1995-01-11 Online:1996-01-24 Published:1996-01-24

PDF (PC)

被引次数

4

关键词: 天冬氨酸衍生物, 胱氨酸衍生物, 钆(Ⅲ)配合物, 弛豫性能

Abstract: Two amino acid derivative ligands,ethylenediamine-N,N′-disuccinic acid(EDDS)and N,N,N′,N′-tetrahydroxyethylcystine(THEC),were synthesized from the reaction ofL-aspartic acid with 1,2-dibromoethane and L-cystine with chloroethanol respectively. Theirparamagnetic gadolinium(Ⅲ) complexes were prepared by the reaction of the ligands with Gd2O3 and Gd(OAc)3 respectively. The ligands and their Gd(Ⅲ) complexes were character-ized by IR,1HNMRspectroscopy and elemental analysis. The proton relaxivity of the com-plexes was investigated, and the R1 values of Gd(Ⅲ)-EDDSand Gd(Ⅲ)-THECare 10.33and 6.62 mmol-1·L·s-1,respectively.

Key words: Aspartic acid derivative, Cystine derivative, Gd(Ⅲ)complex, Relaxivity

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