酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能

doi:10.3969/j.issn.0251-0790.2012.04.000

高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (04): 663.doi: 10.3969/j.issn.0251-0790.2012.04.000

酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能

郝志峰¹, 吴雅红¹, 汪朝阳², 黄卓亮¹, 余坚¹, 余林¹

1. 广东工业大学轻工化工学院, 广州 510006;
2. 华南师范大学化学与环境学院, 广州 510006

收稿日期:2011-08-16 出版日期:2012-04-10 发布日期:2012-04-10
作者简介:郝志峰, 女, 博士, 教授, 主要从事功能配合物研究. E-mail:haozhifeng3377@163.com
基金资助:
国家自然科学基金(批准号: 21101032)和广东省自然科学基金(批准号: 06021469)资助.

Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA

HAO Zhi-Feng¹, WU Ya-Hong¹, WANG Zhao-Yang², HUANG Zhuo-Liang¹, YU Jian¹, YU Lin¹

1. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;
2. School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China

Received:2011-08-16 Online:2012-04-10 Published:2012-04-10
Supported by:
国家自然科学基金(批准号: 21101032)和广东省自然科学基金(批准号: 06021469)资助.

摘要/Abstract

摘要： 以寡聚二乙撑三胺-N,N′-二(乙酰苯胺)-N,N′,N″-三乙酸([H₃L]_n)为配体, 与GdCl₃在二甲基甲酰胺-水混合溶剂中组装得到了寡聚金属螯合物. 采用傅里叶变换红外光谱(FTIR)、元素分析、核磁共振氢谱(¹H NMR)和热重及差热分析(TG-DTA)确定了寡聚金属螯合物的组成单元为[GdL(H₂O)]·4H₂O, 即寡聚配体的每个链节与1个金属离子配位. 采用反转恢复法测试了寡聚金属螯合物和小分子配合物Gd-DTPA(DTPA为二乙撑三胺五乙酸)的纵向弛豫时间T₁, 该寡聚金属螯合物体外弛豫率为8.526 mmol·L^-1·s^-1, 与配合物Gd-DTPA的弛豫率(4.370 mmol·L^-1·s^-1) 相比, 弛豫性能明显提高.

关键词: 酰化聚合反应, 寡聚配合物, Gd(Ⅲ)配合物, 弛豫性能

Abstract: An oligomeric complex was prepared via assembly reaction of oligomeric diethylenetriamine-N,N′-di(acetyl-p-aniline)-N,N′,N″-triacetic acid [H₃L]_n with GdCl₃in DMF-H₂O mixed solvent. The composition unit of the complex was confirmed to be [GdL(H₂O)]·4H₂O after characterized by Fourier transform infrared spectroscope(FTIR), elemental analysis, ¹H NMR, thermal gravimetric and differential thermal analysis(TG-DTA), which showed that every unit of the oligomeric ligand was coordinated to one metal ion. The longitudinal relaxivity time T₁ of oligomeric Gd complex and Gd-DTPA(DTPA is diethylene triamine pentaacetic acid ) were tested by inversion recovery. The results indicated that the relaxivity R₁ of the oligomeric Gd complex was 8.526 mmol·L^-1·s^-1, which was greater than small molecular weight complex Gd-DTPA(4.370 mmol·L^-1·s^-1).

Key words: Acylated polymerization, Oligomeric complex, Gd(Ⅲ) complex, Relaxation property

中图分类号:

O614.33

TrendMD:

郝志峰, 吴雅红, 汪朝阳, 黄卓亮, 余坚, 余林. 酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能. 高等学校化学学报, 2012, 33(04): 663.

HAO Zhi-Feng, WU Ya-Hong, WANG Zhao-Yang, HUANG Zhuo-Liang, YU Jian, YU Lin. Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA. Chem. J. Chinese Universities, 2012, 33(04): 663.

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酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能

Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA

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