高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (6): 900.

• 论文 • 上一篇    下一篇

N-硅甲基-N-甲酰基苯胺衍生物的合成和生物活性研究

张增佑1, 尚坚2, 周秀中2   

  1. 1. 南开大学元素有机化学研究所, 天津, 300071;
    2. 南开大学化学系
  • 收稿日期:1994-06-29 修回日期:1995-02-12 出版日期:1995-06-24 发布日期:1995-06-24
  • 通讯作者: 张增佑,男,56岁,副教授.
  • 作者简介:张增佑,男,56岁,副教授.
  • 基金资助:

    国家自然科学基金

Studies on Synthesis and Biological Activities of N-Silylmethyl-N-formyl Aniline Derivatives

ZHANG Zeng-You1, SHANG Jian2, ZHOU Xiu-Zhong2   

  1. 1. Inst.of Elemento-Org.Chem.of Nankai Univ., Tianjin, 300071;
    2. Chem.Dept.of Nankai Univ.
  • Received:1994-06-29 Revised:1995-02-12 Online:1995-06-24 Published:1995-06-24

PDF (PC)

被引次数

3

摘要： 研究了醇钠存在下取代苯胺与氯甲基硅烷在二甲基甲酰胺中的反应.反应产物经元素分析、IR和1HNMR光谱鉴定为N-硅甲基-N-甲酰基苯胺衍生物.合成了23种通式为RR′R″SiCH2N(CHO)的新化合物,对其中17种进行了生物活性试验.结果表明,个别化合物具有良好的杀菌活性,如p-FC6H4Si(Me2)CH2N(CHO)·C6H4Cl-p在0.005%即可100%杀死芦笋茎枯病菌.

关键词: 氯甲基硅烷, 二甲基甲酰胺, 苯胺, 缩合反应

Abstract: In the presence of the reaction of chloromethylsilanes with substituted anilines in DMF was studied. By means of elementary analysis,IR and 1HNMR,the products of these reaction are confirmed to be N-silylmethyl-N-formyl aniline derivatives.Twenty-three new compounds(with the general formula:RR'R″SiCH2N·where R=CH3;R'=CH3,p-ClC6H4;R″=p-ClC6H4,p-FC6H4,C6H5;Xand Yare H,CH3,Cl,Frespectively.)have been synthesized.The biological activities of some compounds have been tested,a few of them have good germicidal activities.thus p-FC6H4Si(Me2)CH2N(CHO)C6H4Cl-p at 0.005% gave 100% control of Asparagus stem blight.

Key words: Chloromethylsilane, Dimethylformamide, Benzenamine, Condensation

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