高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (6): 806.

• 研究简报 • 上一篇    下一篇

7,10-二芳基-六氢(四氢)苯并[C]吖啶-8-酮的合成

王进军1, 韩光范2, 尹荣2, 姜贵吉3   

  1. 1. 吉林化工学院精细化工系;
    2. 吉林医学院医学检验系;
    3. 延边大学化学系, 延吉 133002
  • 收稿日期:1992-05-19 修回日期:1993-03-09 出版日期:1993-06-24 发布日期:1993-06-24
  • 通讯作者: 姜贵吉

Syntheses of 7,10-Diaryl-hexahydro(tetrahydro)benzo[C]acridin-8-ones

WANG Jin-Jun1, HAN Guang-Fan2, YIN Rong2, JIANG Gui-Ji3   

  1. 1. Dept, of Fine Chem.Technology, Jilin Chem.Industry Instu;
    2. Dept.of Medical Lab., Jilin Medial College;
    3. Department of Chemistry, Yanbian University, Yanji, 133002
  • Received:1992-05-19 Revised:1993-03-09 Online:1993-06-24 Published:1993-06-24

PDF (PC)

被引次数

5

关键词: 苯并吖啶酮, 有机合成, 抗癌活性

Abstract: Syntheses of 7, 10-diaryl-7,8,9,10,11, 12-hexahydro-benzo[C]acridin-8-ones (la-g) were achieved by reaction of 5-aryl-1, 3-cyclohexanedione, α-naphthylamine and the appropriate aromatic aldehydes in ethanol or benzene.The oxidation of compounds la-g with CrO3 in acetic acid giving 7, 10-diaryl-8, 9, 10, 11-tetrahydrobenzo[C]-acridin-8-ones (2a-g) is also reported.The structures of 14 new compounds were characterized by elementary analysis, IR, and 1H NMRspectra.The preliminary pharmacodynamic experiments show that compounds Ic, 1f, 2f possess a significant inhibition effect on the growth of KBcell.

Key words: Benzoacridinone, Organic synthesis, Anticancer activity

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