高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (3): 352.

• 论文 • 上一篇    下一篇

2-[二-(2-氯乙基)-胺基]-5-苄氧基-1,3,2-氧氮磷杂环己烷-2-氧化物的不对称合成

陈茹玉, 张鸣   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1991-03-26 出版日期:1992-03-24 发布日期:1992-03-24
  • 通讯作者: 陈茹玉
  • 基金资助:

    国家博士后科学基金;国家自然科学基金

Asymmetric Synthesis of 2-(Bis-(2-Chloroethyl)-Amino)-5- Benzyloxytetrahydro-2H-1, 3,2-Oxazaphosphorine-2-Oxide

CHEN Ru-yu, ZHANG Ming   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1991-03-26 Online:1992-03-24 Published:1992-03-24

关键词: 不对称合成, 抗癌药物, 酒石酸

Abstract: A novel synthetic route of all enantiomers of 2-(bis-(2-chloroethyl)-amino)-5-benzy-loxy-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide starting from the natural L-tartaric acid as a chiral synthon is described.The results relating to the structures of the intermediates and products in this synthesis are discussed.

Key words: Asymmetric synthesis, Antitumor agent, Tartaric acid

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