高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (2): 202.

• 论文 • 上一篇    下一篇

N,N-二甲酰基-α-氨基苯乙酮与芳醛的羟醛缩合反应及3-羟基-2-甲酰氨基-1,3-二苯基-1-丙酮的晶体结构

韩应琳1, 胡宏纹1, 周忠远2, 郁开北2   

  1. 1. 南京大学化学系, 210008;
    2. 中国科学院成都分析测试中心
  • 收稿日期:1989-10-13 出版日期:1991-02-24 发布日期:1991-02-24
  • 通讯作者: 韩应琳

The Aklol Condensation of N,N-Diformyl a-Amino Acetophenone with Aromatic Aldehydes and the Crystal Structure of 1,3-Diphenyl-2-formylamino-3-hydroxy-1-propanone

Han Ying-lin1, Hu Hong-wen1, Zhou Zhong-yuan2, Yu Kai-bei2   

  1. 1. Department of Chemistry, Nanjing University, Nanjing, 210008;
    2. Chengdu Center of Analysis and Test, Academic Sinica, Chengdu
  • Received:1989-10-13 Online:1991-02-24 Published:1991-02-24

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摘要： 研究了N,N-二甲酰基-α氨基苯乙酮与芳醛的羟醛缩合反应,得到5种控醛缩合产物,并用X-射线单晶衍射法测定了3-羟基-2-甲酰氨基-1,3-二苯-1-丙酮的晶体和分子结构.晶体的空间群为P1;晶体学数据:a=10.802(2)Å,b=11.088(2)Å,c=14.395(3)Å,α=68.20(1)°,β=69.19(1)°,γ=64.35(1)°;V=1403.7(0.5)Å3;Dc=1.27g/cm-3.Z=4.F(000)=567.92(e).μ(MoKa)=0.83cm-1。

关键词: 羟醛缩合, 芳醛, 晶体结构, 3-羟基-2-甲酰氨基-1, 3-二苯-1-丙酮

Abstract: Five new aldol products were obtained by the condensation of N,N-diformyl a-amino ace-tophenone (1) with aromatic aldehydes in the presence of a catalytic amount of potassium hydroxide in methanol and the crystal and molecular structure of 1, 3-diphenyl-2-formylamino-3-hydroxy-1-propanone(3a) was determined by X-ray crystallography on a four-circle diffractometer. The crystal belongs to space group P1with lattice parameters: a=10. 802(2)Å, 6=11. 088(2)Å, c=14. 395 (3)Å, α=68. 20(1)°, β=69.19(1)°, γ=64. 35(1)°; V=1403. 7(0. 5)Å3; Dc=1. 27 g/cm3. Z=4, F(000)=567. 92(e). The structure was refined by the block-matrix least-squares, the final R=0.046.

Key words: Aldol condensation, Aromatic aldehyde, Crystal structure, l,3-Diphenyl-2-form ylamino-3-hydroxy-1-propanone

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